Exploring the role of white matter connectivity in cortex maturation
Exploring the role of white matter connectivity in cortex maturation
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DOI：
10.1371/journal.pone.0177466
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发表时间：
2017-05-17
期刊：
影响因子：
3.7
通讯作者：
Hagmann, Patric
中科院分区：
文献类型：
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作者：
Friedrichs-Maeder, Cecilia L.;Griffa, Alessandra;Hagmann, Patric
皮层灰质（GM）和白质（WM）的成熟被描述为遵循多种但不同规则的连续过程。然而，无论是驱动大脑成熟过程的机制，还是GM和WM成熟之间的关系，都没有得到很好的理解。本研究采用连接组学和反映成熟相关大脑微观结构变化的两种MRI测量方法，即表观扩散系数（ADC）和T1弛豫时间（T1），来研究大脑发育。我们报告说，GM和WM成熟的进展是相互关联的，并依赖于潜在的大脑连接结构。特别是，转基因区域及其事件WM连接显示出相应的成熟水平，通过WM束连接的转基因区域也观察到这一点。基于这些观察，我们提出了一个简单的计算模型，支持连接体在从外部刺激依次传播成熟信号，通过初级感觉结构到高阶功能皮层中的关键作用。
The maturation of the cortical gray matter (GM) and white matter (WM) are described as sequential processes following multiple, but distinct rules. However, neither the mechanisms driving brain maturation processes, nor the relationship between GM and WM maturation are well understood. Here we use connectomics and two MRI measures reflecting maturation related changes in cerebral microstructure, namely the Apparent Diffusion Coefficient (ADC) and the T1 relaxation time (T1), to study brain development. We report that the advancement of GM and WM maturation are inter-related and depend on the underlying brain connectivity architecture. Particularly, GM regions and their incident WM connections show corresponding maturation levels, which is also observed for GM regions connected through a WM tract. Based on these observations, we propose a simple computational model supporting a key role for the connectome in propagating maturation signals sequentially from external stimuli, through primary sensory structures to higher order functional cortices.