Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension
Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension
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DOI：
10.1253/circj.cj-11-1217
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发表时间：
2012-02-01
影响因子：
3.3
通讯作者：
Shimokawa, Hiroaki
中科院分区：
文献类型：
--
作者：
Sugimura, Koichiro;Fukumoto, Yoshihiro;Shimokawa, Hiroaki
背景：远端型慢性血栓栓塞性肺动脉高压（CTEPH）是一种致命性疾病，需要开发新的治疗策略。我们检查了经皮腔内肺血管成形术（PTPA）的效果。方法和结果：我们前瞻性地招募了12例远端型CTEPH患者。在使用肺血管扩张剂稳定病情后，我们进行了PTPA，血管造影和光学相干断层扫描证实，PTPA显著改善了肺血流动力学和肺动脉结构，与39名历史对照相比，PTPA也显著改善了他们的长期预后。结论：PTPA是治疗远端型CTEPH的有效方法。（cirj 2012; 76: 485-488）
Background: Distal-type chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease for which a new therapeutic strategy needs to be developed. We examined the effects of percutaneous transluminal pulmonary angioplasty (PTPA).Methods and Results: We prospectively enrolled 12 patients with distal-type CTEPH. After stabilizing their condition with pulmonary vasodilators, we then performed PTPA, which markedly improved pulmonary hemodynamics and pulmonary artery structure, as confirmed by angiography and optical coherence tomography, and also significantly improved their long-term prognosis compared with 39 historical controls.Conclusions: PTPA is a promising therapeutic option for distal-type CTEPH. (Circ J 2012; 76: 485-488)