ACUTE NONLYMPHOCYTIC LEUKEMIA SHOWING ABNORMAL NUCLEAR LOBULATION
ACUTE NONLYMPHOCYTIC LEUKEMIA SHOWING ABNORMAL NUCLEAR LOBULATION
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DOI：
10.1093/ajcp/75.5.684
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发表时间：
1981-01-01
影响因子：
3.5
通讯作者：
KINUMAKI, H
中科院分区：
文献类型：
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作者：
BESSHO, F;FUJIU, M;KINUMAKI, H
对4例伴有核分叶异常的急性非淋巴细胞白血病的超微结构进行了研究。根据法、美、英合作组织（FAB）的分类，在光镜检查基础上将这些病例分为M3型（病例1）、M3变异型（病例2、3）和M5型分化型（病例4）。病例2和病例3的白血病细胞超微结构观察显示，除了内质网和颗粒异常外，还有大束的原纤维，这与急性早幼粒细胞白血病病例的报道一致。大束的原纤维和异常的核分叶似乎也是M3变异的特征。这些结构之间的关系还没有确定。核分叶的确切性质尚不清楚；它似乎与某种内在力量有关，可能是粒细胞或单核细胞核固有的小叶化过早发生的表现。
An ultrastructural study of 4 cases of acute nonlymphocytic leukemia [in children] with abnormal nuclear lobulation was done. These cases were classified as M3 (case 1), M3 variant (cases 2 and 3) and M5, differentiated type (case 4), on the basis of light microscopy according to the FAB [French American British Cooperative Group] classification. Ultrastructural observation of the leukemic cells of cases 2 and 3 showed large bundles of fibrils in addition to abnormalities in the endoplasmic reticulum and granules, as had been reported in cases of acute promyelocytic leukemia. Large bundles of fibrils and abnormal nuclear lobulation also seemed to be characteristic of the M3 variant. The relationship between these structures was not identified. The exact nature of nuclear lobulation is not known; it seems to be related to some kind of intrinsic force and may be a presentation of the premature occurrence of lobulation intrinsic to the granulocyte or monocyte nucleus.