Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation.
Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation.
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DOI：
10.1254/jphs.09295sc
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发表时间：
2010
影响因子：
3.5
通讯作者：
F. Tsuji;M. Murai;K. Oki;H. Inoue;M. Sasano;Hiroyuki Tanaka;N. Inagaki;H. Aono
中科院分区：
文献类型：
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作者：
F. Tsuji;M. Murai;K. Oki;H. Inoue;M. Sasano;Hiroyuki Tanaka;N. Inagaki;H. Aono
我们最近证明，SA 13353，一种瞬时受体电位香草素1（TRPV 1）激动剂，降低了疾病模型中肾损伤，关节炎和脑脊髓炎症状的严重程度。在这里，我们研究了口服SA 13353对脂多糖（LPS）诱导的急性肺损伤和卵白蛋白诱导的过敏性气道炎症中白细胞浸润的影响。在LPS诱导的肺损伤中，SA 13353减弱了中性粒细胞浸润以及TNF-α和CINC-1水平的增加。在过敏性气道炎症中，SA 13353倾向于抑制白细胞浸润，并减弱IL-4和IL-12 p40的增加。这些结果表明，体感TRPV 1可能在肺部炎症中发挥抗炎作用。
We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation. In LPS-induced lung injury, SA13353 attenuated neutrophil infiltration and the increase of TNF-alpha and CINC-1 levels. In allergic airway inflammation, SA13353 tended to inhibit leukocyte infiltration and attenuated the increase of IL-4 and IL-12p40. These results suggest that somatosensory TRPV1 may play an anti-inflammatory role in lung inflammation.