Cattle demographic history modelled from autosomal sequence variation
Cattle demographic history modelled from autosomal sequence variation
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DOI：
10.1098/rstb.2010.0103
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发表时间：
2010-08-27
影响因子：
6.3
通讯作者：
Bradley, Daniel G.
中科院分区：
文献类型：
--
作者：
Murray, Caitriona;Huerta-Sanchez, Emilia;Bradley, Daniel G.
牛遗传变异的地理分布已被广泛描述，并告知驯化的历史。然而，仍然缺乏从这些数据推断的人口模型。在这里，我们描述了从非洲，欧洲和印度的牛的17个基因中取样的37 000 bp的序列多样性。明确不同的人口历史之间的牛indicus和牛的牛，前者显示出较高的多样性统计。我们比较展开的网站频谱在每个使用扩散近似方法模拟，并建立一个最佳拟合模型过去的人口。这意味着在B有一个更早的、可能是冰川引起的种群瓶颈。在B区，金牛座的祖先较晚，可能与驯化有关。indicus。引人注目的是，模拟indicine的历史也需要一个大部分的南亚欧洲野牛二级混合物，表明一个复杂的，更分散的驯化过程。这可能涉及多个驯化和/或渐渗从野生牛到国内畜群;后者是可信的，从考古证据同期野生和国内仍然在不同地区的南亚。
The phylogeography of cattle genetic variants has been extensively described and has informed the history of domestication. However, there remains a dearth of demographic models inferred from such data. Here, we describe sequence diversity at 37 000 bp sampled from 17 genes in cattle from Africa, Europe and India. Clearly distinct population histories are suggested between Bos indicus and Bos taurus, with the former displaying higher diversity statistics. We compare the unfolded site frequency spectra in each to those simulated using a diffusion approximation method and build a best-fitting model of past demography. This implies an earlier, possibly glaciation-induced population bottleneck in B. taurus ancestry with a later, possibly domestication- associated demographic constriction in B. indicus. Strikingly, the modelled indicine history also requires a majority secondary admixture from the South Asian aurochs, indicating a complex, more diffuse domestication process. This perhaps involved multiple domestications and/or introgression from wild oxen to domestic herds; the latter is plausible from archaeological evidence of contemporaneous wild and domestic remains across different regions of South Asia.