Association of Physical Activity by Type and Intensity With Digestive System Cancer Risk
Association of Physical Activity by Type and Intensity With Digestive System Cancer Risk
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DOI：
10.1001/jamaoncol.2016.0740
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发表时间：
2016-09-01
期刊：
影响因子：
28.4
通讯作者：
Giovannucci, Edward L.
中科院分区：
文献类型：
--
作者：
Keum, Nana;Bao, Ying;Giovannucci, Edward L.
重要性越来越多的证据表明，常见的致癌途径可能是消化系统癌症的基础。身体活动可能会影响这些途径。然而，据我们所知，以前没有研究评估身体活动在整体消化系统癌症风险中的作用。目的研究身体活动与消化系统癌症风险之间的关系，占数量，类型，（有氧运动与阻力运动）和体力活动强度。设计，环境，一项前瞻性队列研究跟踪了1986年至2012年卫生专业人员随访研究中的43479名男性。在登记时，合格的参与者年龄在40岁或以上，没有癌症，并报告了身体活动。随访率超过90%，在每个2年周期。暴露的总体力活动量表示的代谢当量的任务（MET）-小时/周。主要结果和措施的消化系统癌症的发病率包括消化道（口腔、咽喉、食道、胃、小肠和结肠直肠）和消化附属器官结果在686924人年中，我们记录了1370例消化系统癌症事件。较高水平的体力活动与较低的消化系统癌症风险相关（风险比[HR]，≥ 63.0 vs = 63.0 vs
IMPORTANCE Accumulating evidence indicates that common carcinogenic pathways may underlie digestive system cancers. Physical activity may influence these pathways. Yet, to our knowledge, no previous study has evaluated the role of physical activity in overall digestive system cancer risk.OBJECTIVE To examine the association between physical activity and digestive system cancer risk, accounting for amount, type (aerobic vs resistance), and intensity of physical activity.DESIGN, SETTING, AND PARTICIPANTS A prospective cohort study followed 43 479 men from the Health Professionals Follow-up Study from 1986 to 2012. At enrollment, the eligible participants were 40 years or older, were free of cancer, and reported physical activity. Follow-up rates exceeded 90% in each 2-year cycle.EXPOSURES The amount of total physical activity expressed in metabolic equivalent of task (MET)-hours/week.MAIN OUTCOMES AND MEASURES Incident cancer of the digestive system encompassing the digestive tract (mouth, throat, esophagus, stomach, small intestine, and colorectum) and digestive accessory organs (pancreas, gallbladder, and liver).RESULTS Over 686 924 person-years, we documented 1370 incident digestive system cancers. Higher levels of physical activity were associated with lower digestive system cancer risk (hazard ratio [HR], 0.74 for >= 63.0 vs = 63.0 vs