A mixture model for water uptake, degradation, erosion and drug release from polydisperse polymeric networks
A mixture model for water uptake, degradation, erosion and drug release from polydisperse polymeric networks
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DOI：
10.1016/j.biomaterials.2010.01.008
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发表时间：
2010-04-01
期刊：
影响因子：
14
通讯作者：
Zunino, Paolo
中科院分区：
文献类型：
--
作者：
Soares, Joao S.;Zunino, Paolo
我们介绍了一个一般类的混合物模型适合描述水依赖性降解和侵蚀的生物可降解聚合物与药物释放。预测和量化降解和侵蚀的能力在各种生物医学应用中具有直接影响，并且是可生物降解植入物和组织工程支架的有用设计工具。该模型是基于有限数量的成分描述的多分散聚合物系统，每个代表链的平均大小，和两个额外的成分，水和药物。单个链的水解降解发生在分子水平上，并且混合物组分根据Fick第一定律在本体水平上单独扩散-这种分析赋予所得反应扩散系统多尺度方面。两种不同类型的行为之间的转变，每一个确定的表面或散装侵蚀，观察到一个单一的无量纲参数测量的反应和扩散机制的相对重要性的变化。质量损失如下S形减少在本体侵蚀聚合物，而线性减少在表面侵蚀聚合物。多分散性影响本体侵蚀聚合物的降解和侵蚀，并且在侵蚀控制释放中，药物从不稳定的表面侵蚀基质的释放显著增强。(C)2010爱思唯尔有限公司保留所有权利。
We introduce a general class of mixture models suitable to describe water-dependent degradation and erosion of biodegradable polymers in conjunction with drug release. The ability to predict and quantify degradation and erosion has direct impact in a variety of biomedical applications and is a useful design tool for biodegradable implants and tissue engineering scaffolds. The model is based on a finite number of constituents describing the polydisperse polymeric system, each representing chains of an average size, and two additional constituents, water and drug. Hydrolytic degradation of individual chains occurs at the molecular level and mixture constituents diffuse individually accordingly to Fick's 1st law at the bulk level - such analysis confers a multi-scale aspect to the resulting reaction-diffusion system. A shift between two different types of behavior, each identified to surface or bulk erosion, is observed with the variation of a single non-dimensional parameter measuring the relative importance of the mechanisms of reaction and diffusion. Mass loss follows a sigmoid decrease in bulk eroding polymers, whereas decreases linearly in surface eroding polymers. Polydispersity influences degradation and erosion of bulk eroding polymers and drug release from unstable surface eroding matrices is dramatically enhanced in an erosion-controlled release. (C) 2010 Elsevier Ltd. All rights reserved.