Physiological effects of hypervolemic polycythemia in newborn dogs.
Physiological effects of hypervolemic polycythemia in newborn dogs.
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新生犬高容量红细胞增多症的生理影响。
DOI：
10.1152/jappl.1982.53.4.865
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
Kleinman,LI
中科院分区：
文献类型：
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作者：
LeBlanc,MH;Kotagal,UR;Kleinman,LI
研究了16只未麻醉新生犬（3-10日龄）高容性红细胞增多症（Hct 62-77）对氧运输和耗氧量（Vo2）的影响。对照组为10只新生犬（3-10日龄），在其他相同的实验中进行高血容量但不红细胞增多。通过输注33 ml/kg填充红细胞（红细胞增多症）或全血（对照组）达到高血容量。红细胞增多组输血后心输出量（CO）降低50% (P < 0.001)，外周血管阻力（PVR）升高170% (P < 0.001)，但O2转运无明显变化，Vo2仅轻微降低13% （P < 0.01）。在10只对照动物中，由于输血，CO、PVR、O2转运或Vo2没有显著变化。血乳酸浓度在实验组（35%,P < 0.04）和对照组（23%，NS）中仅略有升高。通过测量冷应激引起的变化来测试动物增加氧气运输和Vo2的能力。冷胁迫使增红细胞动物和对照动物的Vo2均增加20% （P < 0.05）。因此，尽管在非应激状态下CO减少，但在冷应激状态下，增红细胞动物仍然能够增加O2转运和Vo2。这些结果表明，新生动物在高血容量、多红细胞性高黏度和环境冷应激条件下，能够调节CO以维持适宜的氧运输。
The effect of hypervolemic polycythemia (Hct 62–77) on O2 transport and O2 consumption (Vo2) was studied in 16 unanesthetized newborn dogs (age 3–10 days). A control group of 10 newborn dogs (3–10 days old) was made hypervolemic but not polycythemic in an otherwise identical experiment. Hypervolemia was attained by infusing 33 ml/kg of either packed red blood cells (polycythemia) or whole blood (controls). In the polycythemic group as a result of the transfusion, cardiac output (CO) decreased by 50% (P less than 0.001), peripheral vascular resistance (PVR) increased by 170% (P less than 0.001), but O2 transport did not change significantly, and Vo2 decreased only slightly by 13% (P less than 0.01). In the 10 control animals there were no significant changes in CO, PVR, O2 transport, or Vo2 as a result of the transfusion. Blood lactate increased only slightly in experimental (35%, P less than 0.04) and control animals (23%, NS). The ability of the animals to increase their O2 transport and Vo2 was tested by measuring the changes induced by cold stress. Cold stress produced a 20% increase in Vo2 (P less than 0.05) in both the polycythemic and the control animals. Thus in spite of a decreased CO in the nonstressed state the polycythemic animals were still able to increase O2 transport and Vo2 in response to cold stress. These results suggest that the newborn animal is capable of regulating CO to maintain O2 transport appropriate to uptake under conditions of hypervolemic, polycythemic hyperviscosity, and environmental cold stress.