In vitro activity of potential anti-poxvirus agents
In vitro activity of potential anti-poxvirus agents
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DOI：
10.1016/s0166-3542(02)00198-5
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发表时间：
2003-01-01
影响因子：
7.6
通讯作者：
Kern, ER
中科院分区：
文献类型：
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作者：
Kern, ER
天花或猴痘等另一种正痘病毒可能被用作生物恐怖主义武器，这促使人们努力开发治疗天花或其他天花病毒感染的新药。目前，只有西多福韦被批准用于天花暴发的紧急治疗。尽管西多福韦在体外和动物模型感染中对正痘病毒非常有效，但口服时不起作用，必须谨慎使用，以避免肾毒性。为了确定这些感染的替代治疗方式，我们测定了大多数批准的抗病毒药物以及一些西多福韦类似物和前药的体外抗痘病毒活性。从这些研究中，我们已经确定了核苷酸类似物、阿德福韦酯、一些西多福韦的烷氧基酯和一些西多福韦的前体药物，这些药物值得进一步研究，作为治疗天花或其他正痘病毒感染的潜在疗法。(C)2002 Elsevier Science B.V.保留所有权利。
The potential use of variola or another orthopoxvirus such as monkeypox as a weapon of bioterrorism has stimulated efforts to develop new drugs for treatment of smallpox or other poxvirus infections. At the present time only cidofovir is approved for use in the emergency treatment of smallpox outbreaks. Although cidofovir is very active against the orthopoxviruses in vitro and in animal model infections, it is not active when given orally and must be administered with precaution so as to avoid renal toxicity. In an attempt to identify alternative treatment modalities for these infections we have determined the anti-poxvirus activity in vitro of most of the approved antiviral agents as well as a number of cidofovir analogs and prodrugs. From these studies, we have identified the nucleotide analog, adefovir dipivoxil, some alkoxyalkyl esters of cidofovir and a number of prodrugs of cidofovir that warrant further investigation as potential therapies for smallpox or other orthopoxvirus infections. (C) 2002 Elsevier Science B.V. All rights reserved.