Cancer in a population-based cohort of men and women in registered homosexual partnerships
Cancer in a population-based cohort of men and women in registered homosexual partnerships
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DOI：
10.1093/aje/kwg067
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发表时间：
2003-06-01
影响因子：
5
通讯作者：
Johansen, C
中科院分区：
文献类型：
--
作者：
Frisch, M;Smith, E;Johansen, C
同性恋男女的癌症模式尚未得到系统的研究。作者在1989年至1997年期间，对丹麦的1,614名女性和3,391名男性进行了癌症跟踪调查，这些人都是第一次登记结婚的同性恋伴侣。观察到的癌症与预期癌症的比率测量相对风险。同性恋伴侣中的女性患癌风险与丹麦女性总体相似（总体相对风险（RR）= 0.9，95%置信区间（CI）：0.6，1.4），但只有1名女性发生宫颈原位癌，而预期为5.8名女性（RR = 0.2，95% CI：0.0，0.97）。总体而言，同性恋伴侣中的男性癌症风险升高（RR = 2.1，95% CI：1.8，2.5），主要是由于人类免疫缺陷病毒（HIV）/获得性免疫缺陷综合征（AIDS）相关的卡波西肉瘤（RR = 136，95% CI：96，186）和非霍奇金淋巴瘤（RR = 15.1，95% CI：10.4，21.4）。肛门鳞状细胞癌的发生率也较高（RR = 31.2，95% CI：8.4，79.8）。排除卡波西肉瘤、非霍奇金淋巴瘤和肛门鳞状细胞癌后，无异常癌症风险（RR = 1.0，95%CI：0.8，1.3）。男性中肛门鳞状细胞癌和艾滋病毒/艾滋病相关癌症是明显的例外，处于婚姻关系中的同性恋者的癌症发病率与整个社会中普遍存在的癌症发病率相似。
Cancer patterns among broad populations of homosexual men and women have not been studied systematically. The authors followed 1,614 women and 3,391 men in Denmark for cancer from their first registration for marriage-like homosexual partnership between 1989 and 1997. Ratios of observed to expected cancers measured relative risk. Women in homosexual partnerships had cancer risks similar to those of Danish women in general (overall relative risk (RR) = 0.9, 95% confidence interval (CI): 0.6,1.4), but only one woman developed cervical carcinoma in situ versus 5.8 women expected (RR = 0.2, 95% CI: 0.0, 0.97). Overall, men in homosexual partnerships were at elevated cancer risk (RR = 2.1, 95% CI: 1.8, 2.5), due mainly to human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma (RR = 136, 95% CI 96,186) and non-Hodgkin's lymphoma (RR = 15.1, 95% CI: 10.4, 21.4). Anal squamous carcinoma also occurred in excess (RR = 31.2, 95% CI: 8.4, 79.8). After exclusion of Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal squamous carcinoma, no unusual cancer risk remained (RR = 1.0, 95% CI: 0.8,.1.3). With anal squamous carcinoma and HIV/AIDS-associated cancers as notable exceptions in men, cancer incidence rates among homosexual persons in marriage-like partnerships are similar to those prevailing in society at large.