Trefoil factors in inflammatory bowel disease
Trefoil factors in inflammatory bowel disease
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DOI：
10.3748/wjg.v20.i12.3223
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发表时间：
2014-03-28
影响因子：
4.3
通讯作者：
Gronbaek, Henning
中科院分区：
文献类型：
--
作者：
Aamann, Luise;Vestergaard, Else Marie;Gronbaek, Henning
炎症性肠病（IBD）包括溃疡性结肠炎和克罗恩病，其特征在于胃肠道的炎症。三叶因子1、2和3（TFF 1 -3）是在保护和修复上皮表面（包括胃肠道）中发挥重要作用的肽家族。TFF可能参与IBD的发病机制，是一种潜在的治疗选择。在本综述中，我们描述了TFF家族及其在IBD中的潜在作用，通过总结目前的知识，他们的表达，可能的功能和药理作用在IBD中。(c)2014百世登出版集团有限公司有限公司All rights reserved.
Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn's disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.