Superfamily 1 helicases .
Superfamily 1 helicases .
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DOI：
10.2741/s367
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Neville S. Gilhooly;Emma J. Gwynn;M. Dillingham
中科院分区：
文献类型：
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作者：
Neville S. Gilhooly;Emma J. Gwynn;M. Dillingham
超家族1解旋酶是将ATP水解与DNA或RNA的移位沿着以及伴随的解旋偶联的核酸马达蛋白。这是细胞DNA和RNA代谢的许多方面的核心，因此，它们涉及广泛的核酸加工事件，包括DNA复制、重组和修复以及RNA代谢的许多方面。本文综述了超家族1解旋酶的结构、功能和作用机制。
Superfamily 1 helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along, and concomitant unwinding of, DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and, accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination and repair as well as many aspects of RNA metabolism. This review discusses our current understanding of the structure, function and mechanism of Superfamily 1 helicases.