Predictors and moderators of treatment response in childhood anxiety disorders: results from the CAMS trial.
Predictors and moderators of treatment response in childhood anxiety disorders: results from the CAMS trial.
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DOI：
10.1037/a0035458
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发表时间：
2014-04
影响因子：
5.9
通讯作者：
Albano AM
中科院分区：
文献类型：
--
作者：
Compton SN;Peris TS;Almirall D;Birmaher B;Sherrill J;Kendall PC;March JS;Gosch EA;Ginsburg GS;Rynn MA;Piacentini JC;McCracken JT;Keeton CP;Suveg CM;Aschenbrand SG;Sakolsky D;Iyengar S;Walkup JT;Albano AM
在488名7-17岁的青少年中检查治疗结果的预测因素和调节因素（50%为女性; 74% ≤ 12岁），DSM-IV诊断为分离焦虑症、社交恐怖症或广泛性焦虑症，随机分配接受认知行为治疗（CBT）、舍曲林（SRT）、两者联合治疗（COMB），或在儿童/青少年焦虑多模式研究（CAMS）中使用药丸安慰剂（PBO）进行药物管理。从文献中确定了6类预测变量和调节变量（22个变量），并使用连续（儿科焦虑评定量表; PARS）和分类（临床总体印象量表-改善; CGI-I）结局指标进行了检查。三个基线变量预测了PARS的更好结果（独立于治疗条件），包括低焦虑严重程度（由父母和独立评估者测量）和照顾者压力。未发现基线变量可预测第12周应答状态（CGI-I）。参与者的主要诊断调节治疗结果，但仅在PARS上。在第12周应答者状态（CGI-I）中，未发现中度治疗结局的基线变量。总体而言，焦虑的儿童对CAMS治疗反应良好。然而，有更严重和损害性的焦虑，更大的照顾者压力，以及社交恐惧症的主要诊断与不太有利的结果。这些研究结果的临床意义进行了讨论。
To examine predictors and moderators of treatment outcomes among 488 youth ages 7-17 years (50% female; 74% ≤ 12 years) with DSM-IV diagnoses of separation anxiety disorder, social phobia, or generalized anxiety disorder who were randomly assigned to receive either cognitive behavior therapy (CBT), sertraline (SRT), their combination (COMB), or medication management with pill placebo (PBO) in the Child/Adolescent Anxiety Multimodal Study (CAMS). Six classes of predictor and moderator variables (22 variables) were identified from the literature and examined using continuous (Pediatric Anxiety Ratings Scale; PARS) and categorical (Clinical Global Impression Scale-Improvement; CGI-I) outcome measures. Three baseline variables predicted better outcomes (independent of treatment condition) on the PARS, including low anxiety severity (as measured by parents and independent evaluators) and caregiver strain. No baseline variables were found to predict week 12 responder status (CGI-I). Participant's principal diagnosis moderated treatment outcomes, but only on the PARS. No baseline variables were found to moderate treatment outcomes on week 12 responder status (CGI-I). Overall, anxious children responded favorably to CAMS treatments. However, having more severe and impairing anxiety, greater caregiver strain, and a principal diagnosis of social phobia were associated with less favorable outcomes. Clinical implications of these findings are discussed.
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影响因子：
5.9
作者：
Barrett, PM;Dadds, MR;Rapee, RM
通讯作者：
Rapee, RM
DOI：
10.1016/j.chc.2005.06.003
发表时间：
2005-10-01
影响因子：
2.4
作者：
Costello, EJ;Egger, HL;Angold, A
通讯作者：
Angold, A
DOI：
10.1089/104454603322126313
发表时间：
2003-01-01
影响因子：
1.9
作者：
Geller, DA;Biederman, J;Carpenter, D
通讯作者：
Carpenter, D
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
7.6
作者：
Ezpeleta, L;Keeler, G;Angold, A
通讯作者：
Angold, A