EEG-correlated fMRI of human alpha activity
EEG-correlated fMRI of human alpha activity
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DOI：
10.1016/s1053-8119(03)00286-6
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发表时间：
2003-08-01
期刊：
影响因子：
5.7
通讯作者：
Krakow, K
中科院分区：
文献类型：
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作者：
Laufs, H;Kleinschmidt, A;Krakow, K
脑电相关功能磁共振成像(EEG/fMRI)可用于识别与生理性和病理性脑电事件相关的血氧水平依赖(BOLD)信号变化。在这里，我们实施了连续和同步的EEG/fMRI来识别与阿尔法节律(8-12赫兹)的自发功率波动相关的大胆信号变化，阿尔法节律是放松清醒期间的主要脑电模式。在1.5T磁共振(MR)扫描仪中，使用与MR兼容的脑电记录系统，记录了10名受试者闭眼休息时的32个脑电通道。回波平面成像功能扫描几乎每隔4天就覆盖整个大脑。在功能磁共振成像采集过程中，应用离线磁共振伪影减影软件获得连续的脑电数据。利用快速傅立叶变换，得到了在几个电极位置的1-S历元的平均α功率。然后将功率时间历程与典型血流动力学响应函数卷积，下采样，并用于图像时间序列中相关信号变化的统计参数映射。在所研究的所有电极位置，顶叶和额叶皮质活动与阿尔法功率呈强烈的负相关。相反，只有稀疏和非系统的正相关被检测到。鉴于目前关于阿尔法节律的产生和意义的理论以及相关的功能神经成像发现，这些发现的相关性被讨论。(C)2003 Elsevier Inc.保留所有权利。
Electroencephalography-correlated functional magnetic resonance imaging (EEG/fMRI) can be used to identify blood oxygen level-dependent (BOLD) signal changes associated with both physiological and pathological EEG events. Here, we implemented continuous and simultaneous EEG/fMRI to identify BOLD signal changes related to spontaneous power fluctuations in the alpha rhythm (8-12 Hz), the dominant EEG pattern during relaxed wakefulness. Thirty-two channels of EEG were recorded in 10 subjects during eyes-closed rest inside a 1.5-T magnet resonance (MR) scanner using an MR-compatible EEG recording system. Functional scanning by echoplanar imaging covered almost the entire cerebrum every 4 s. Off-line MRI artifact subtraction software was applied to obtain continuous EEG data during fMRI acquisition. The average alpha power over 1-s epochs was derived at several electrode positions using a Fast Fourier Transform. The power time course was then convolved with a canonical hemodynamic response function, down-sampled, and used for statistical parametric mapping of associated signal changes in the image time series. At all electrode positions studied, a strong negative correlation of parietal and frontal cortical activity with alpha power was found. Conversely, only sparse and nonsystematic positive correlation was detected. The relevance of these findings is discussed in view of the current theories on the generation and significance of the alpha rhythm and the related functional neuroimaging findings. (C) 2003 Elsevier Inc. All rights reserved.