Transient activation of inferior prefrontal cortex during cognitive set shifting
Transient activation of inferior prefrontal cortex during cognitive set shifting
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DOI：
10.1038/283
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发表时间：
1998-05-01
影响因子：
25
通讯作者：
Miyashita, Y
中科院分区：
文献类型：
--
作者：
Konishi, S;Nakajima, K;Miyashita, Y
威斯康星州卡片分类测试（英语：Card Sorting Test）是用来检测人类额叶病变的最常见的测试，它检测的是将注意力从一类刺激属性转移到另一类刺激属性的能力（转移认知集合）。然而，这种卡片测试与前额叶功能的确切关系以及所涉及的认知转变的精确解剖定位是有争议的。利用功能磁共振成像的时间分辨率分离出与移位相关的信号，我们可重复地发现双侧额下沟后部的瞬时激活，这种激活随着维度（必须识别的相关刺激属性）的增加而增加。这些结果表明，额下区在认知集合的灵活移位中起着重要作用。
The Wisconsin Card Sorting Test, which probes the ability to shift attention from one category of stimulus attributes to another (shifting cognitive sets), is the most common paradigm used to detect human frontal lobe pathology. However, the exact relationship of this card test to prefrontal function and the precise anatomical localization of the cognitive shifts involved are controversial. By isolating shift-related signals using the temporal resolution of functional magnetic resonance imaging, we reproducibly found transient activation of the posterior part of the bilateral inferior frontal sulci, This activation was larger as the number of dimensions (relevant stimulus attributes that had to be recognized) were increased, These results suggest that the inferior frontal areas play an essential role in the flexible shifting of cognitive sets.