PET imaging of prostate cancer using carbon-11-choline.
PET imaging of prostate cancer using carbon-11-choline.
复制标题
使用碳 11 胆碱对前列腺癌进行 PET 成像。
DOI：
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复制
发表时间：
1998
影响因子：
9.3
通讯作者：
Hiroichi Kishi
中科院分区：
文献类型：
--
作者：
T. Hara;N. Kosaka;Hiroichi Kishi
未标记
前列腺癌是很难可视化使用目前的技术。最近，31 P磁共振光谱显示，一般来说，肿瘤的特征是细胞对胆碱的摄入增加，以满足磷脂酰胆碱（一种重要的细胞膜磷脂）合成的增加。我们成功地使用11 C-胆碱在PET中显示前列腺癌及其局部转移。
方法
对10例前列腺癌患者进行了从骨盆水平到下腹部的PET检查。透射扫描后静脉注射11 C-胆碱370 MBq。注射后5-15 min进行发射扫描。最后，显示PET图像，使得每个像素用代表标准化摄取值（SUV）程度的指定颜色着色。将11 C-胆碱图像与从同一患者获得的18 F-氟脱氧葡萄糖（FDG）图像进行比较。
结果
当使用18F-FDG时，前列腺癌及其局部转移的成像是困难的，因为在骨盆内，高摄取区域被尿液（输尿管和膀胱）中压倒性的丰富放射性所掩盖。相比之下，当使用11 C-胆碱时，这很容易，因为尿液活动可以忽略不计，肿瘤摄取明显。在大多数情况下，前列腺癌和转移部位的11 C-胆碱放射性浓度的SUV大于3。18F-FDG的SUV显著低于11 C-胆碱。
结论
使用11 C-胆碱在PET中清楚地显示前列腺癌及其局部转移。
UNLABELLED
Prostate cancer is difficult to visualize using current techniques. Recently, 31P magnetic resonance spectroscopy has revealed that the tumor, in general, is characterized by an increased uptake of choline into the cell to meet increased synthesis of phosphatidylcholine, an important cell membrane phospholipid. We succeeded in using 11C-choline to visualize prostate cancer and its local metastasis in PET.
METHODS
PET was performed on 10 prostate cancer patients from the level of pelvis to the lower abdomen. After transmission scanning, 370 MBq 11C-choline were injected intravenously. The emission scan was performed 5-15 min postinjection. Finally, PET images were displayed so that each pixel was painted by a specified color representing the degree of the standardized uptake value (SUV). The 11C-choline image was compared with the 18F-fluorodeoxyglucose (FDG) image obtained from the same patient.
RESULTS
Imaging of prostate cancer and its local metastasis was difficult when 18F-FDG was used because, within the pelvis, the areas of high uptake were concealed by the overwhelmingly abundant radioactivity in urine (in ureters and bladder). By contrast, it was easy when 11C-choline was used because the urinary activity was negligible and tumor uptake was marked. The radioactivity concentration of 11C-choline in prostate cancer and metastatic sites was at an SUV of more than three in most cases. The SUV of 18F-FDG was considerably lower than that of 11C-choline.
CONCLUSION
Prostate cancer and its local metastasis were visualized clearly in PET using 11C-choline.
磷酸单酯代谢作为细胞增殖状态和外源前体的函数。
DOI：
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发表时间：
1996
期刊：
Anticancer research.
影响因子：
--
作者：
Aiken,NR;Gillies,RJ
通讯作者：
Gillies,RJ
Harvey-ras 癌基因转染的 C3H10T1/2 细胞中磷脂酰胆碱代谢发生改变。
DOI：
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发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Teegarden,D;Taparowsky,EJ;Kent,C
通讯作者：
Kent,C
T47D 人乳腺癌细胞中的脂质代谢：胆碱和乙醇胺摄取的 31P 和 13C-NMR 研究。
DOI：
10.1016/0167-4889(91)90038-y
发表时间：
1991
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Ronen,SM;Rushkin,E;Degani,H
通讯作者：
Degani,H