Treatment approaches to symptoms associated with frontotemporal degeneration.
Treatment approaches to symptoms associated with frontotemporal degeneration.
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DOI：
10.1007/s11920-005-0040-5
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发表时间：
2005-10-01
影响因子：
6.7
通讯作者：
Chow, Tiffany W
中科院分区：
文献类型：
--
作者：
Chow, Tiffany W
对文献的系统回顾显示，针对额颞叶变性（FTD）药物治疗的随机对照试验很少。尽管有证据支持血清素能缺陷，并且临床医生经常给 FTD 患者开选择性血清素再摄取抑制剂，但仅对帕罗西汀和曲唑酮进行了研究。尽管没有一致的证据表明这种疾病存在胆碱能缺陷，但有 II 类证据表明卡巴拉汀可用于治疗 FTD 行为障碍。
A systematic review of the literature reveals few randomized, controlled trials for drug therapy in frontotemporal degeneration (FTD). Although there is evidence to support a serotonergic deficit, and clinicians frequently prescribe selective serotonin reuptake inhibitors to patients with FTD, only paroxetine and trazodone have been studied. There is Class II evidence for use of rivastigmine in FTD behavioral disturbances, although there is no consistent evidence of cholinergic deficit in this illness.