Rising prevalence of hepatitis C virus infection among patients recently diagnosed with hepatocellular carcinoma in the United States
Rising prevalence of hepatitis C virus infection among patients recently diagnosed with hepatocellular carcinoma in the United States
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DOI：
10.1097/00004836-200209000-00013
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发表时间：
2002-09-01
影响因子：
2.9
通讯作者：
El-Serag, HB
中科院分区：
文献类型：
--
作者：
Hassan, MM;Frome, A;El-Serag, HB
背景：本研究的目的是确定丙型肝炎病毒（HCV）是否是美国肝细胞癌（HCC）发病率增加的潜在原因。研究：回顾了1993年至1998年在美国德克萨斯州休斯顿的德克萨斯大学安德森癌症中心接受肝细胞癌病理诊断的所有患者的医疗记录。仅分析了居住在美国的患者。所有患者均检测了丙型肝炎病毒和乙型肝炎病毒血清学标志物。结果：md安德森癌症中心的HCC患者数量从1993年至1995年的143例增加到1996年至1998年的216例。1993 - 1995年和1996 - 1998年，分别有26例（18%）和66例（31%）抗hcv抗体被诊断为HCC，显著增加（p = 0.01）。尽管这些患者的年龄分布在1993 - 1995年和1996 - 1998年之间没有显著差异，但hcv相关HCC的增加在40 - 49岁的患者中最大。1993 ~ 1995年肝癌37例（26%）和1996 ~ 1998年肝癌37例（17%）检出乙肝表面抗原（HBsAg）或抗乙肝核心抗原（p = 0.06）。此外，与1993年至1995年（25例，18%）相比，1996年至1998年（21例，10%）HBsAg的患病率显著下降（p = 0.03）。结论：在这项以美国为中心的大规模单中心研究中，丙型肝炎感染是导致HCC发病率增加的主要病毒因素。
Background: The aim of this study was to determine whether hepatitis C virus (HCV) is an underlying cause of the increase in the incidence of hepatocellular carcinoma (HCC) in the United States. Study: The medical records of all patients who had received a pathologic diagnosis of HCC at the University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A., during 1993 through 1998 were reviewed. Only patients residing in the United States were analyzed. All patients were tested for HCV and hepatitis B virus serologic markers. Results: The number of patients with HCC referred to M.D. Anderson Cancer Center increased from 143 in 1993 through 1995 to 216 in 1996 through 1998. Twenty-six patients (18%) and 66 patients (31%) with anti-HCV antibodies were diagnosed with HCC from 1993 to 1995 and from 1996 to 1998, respectively, thus constituting a significant increase (p = 0.01). Although the age distribution of these patients did not differ significantly between 1993 to 1995 and 1996 to 1998, the increase in HCV-associated HCC was greatest among patients 40 to 49 years old. Hepatitis B surface antigens (HBsAg) or anti-hepatitis B core antigens were found in 37 patients (26%) with HCC during 1993 to 1995 and in 37 patients (17%) with HCC during 1996 to 1998 (p = 0.06). Moreover, a significant decrease in the prevalence of HBsAg from 1996 to 1998 (21 patients; 10%) compared with 1993 to 1995 (25 patients; 18%) was observed (p = 0.03). Conclusion: Hepatitis C infection is the major viral factor contributing to the increase in HCC incidence observed in this large-scale, single-center United States-based experience.