Moderating effect of cognitive reserve on the association between grey matter atrophy and memory varies with age in older adults
Moderating effect of cognitive reserve on the association between grey matter atrophy and memory varies with age in older adults
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DOI：
10.1111/psyg.12460
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发表时间：
2020-01-01
期刊：
影响因子：
2
通讯作者：
Chey, Jeanyung
中科院分区：
文献类型：
--
作者：
Kwak, Seyul;Shin, Minyoung;Chey, Jeanyung
背景教育程度和言语智力间接反映一个人的认知储备(CR)，被认为可以缓冲晚年大脑退化对认知表现结果的影响。我们的目的是探索在健康的老年人中，整体灰质体积(GMV)和情景记忆功能之间的关系是如何被CR替代物和年龄改变的。方法对110名社区老年人进行老年言语学习测验(EVLT)和结构磁共振成像检查。缓和调节模型测试整体GMV和情节记忆之间的联系是否同时受到CR和时间顺序年龄的调节。结果认知记忆对EVLT的即刻回忆、短时回忆和再认成绩的调节作用因年龄段不同而异。在年龄-年轻状态下，CR高的老年人对EVLT的GMV效应更大，而在老年-老年状态下，这种调节作用则相反，提示CR高的老年人的脑萎缩效应减轻。结论CR值越高的老年人GMV相关记忆减退的时间越早，但CR对脑萎缩所致认知功能减退的缓冲作用在可能积累更多神经病变的老年人群中更为明显。这项研究强调，在研究CR在晚年记忆功能中的调节作用时，年龄是一个重要的调节因素。
Background Educational attainment and verbal intelligence, which indirectly reflect an individual's cognitive reserve (CR), is suggested to buffer the effect of late-life brain degradation on cognitive performance outcome. We aimed to explore how the relationship between whole grey matter volume (GMV) and episodic memory function is altered by CR proxy as well as age in healthy older adults. Methods Elderly Verbal Learning Test (EVLT) and structural magnetic resonance imaging were administered to 110 community-residing older adults. Moderated moderation model tested whether the association between whole GMV and episodic memory was moderated by both CR and chronological age. Results The results showed that the moderating effect of CR on Immediate Recall, Short-delay Recall, and Recognition scores of EVLT differed across age groups. The elderly with higher CR showed steeper GMV effect on EVLT at the Age-Younger condition, while such moderating effect was reversed in the Age-Older condition, suggesting an alleviated brain atrophy effect in higher CR elderly. Conclusion These findings suggest that although higher CR elderly may exhibit earlier GMV-related memory decline, the buffering effect of CR on the cognitive decline due to brain atrophy would become more evident in old-old elderly people who are likely to have accumulated more neuropathological changes. This study underscores chronological age as an important moderating factor in examining the moderating role of CR in late-life memory function.