Metabolic imaging of mild traumatic brain injury
Metabolic imaging of mild traumatic brain injury
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DOI：
10.1007/s11682-012-9181-4
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发表时间：
2012-06-01
影响因子：
3.2
通讯作者：
Ross, B. D.
中科院分区：
文献类型：
--
作者：
Lin, A. P.;Liao, H. J.;Ross, B. D.
创伤性脑损伤导致发生在分子水平上的代谢级联变化，这是传统成像方法（如计算机断层扫描或磁共振成像）所不可见的。非侵入性代谢成像工具，如单光子发射计算机断层扫描（SPECT），正电子发射断层扫描（PET）和磁共振波谱（MRS）是提供洞察这些变化的理想方法，通过测量局部脑血流量，葡萄糖代谢和脑代谢物浓度，分别在轻度创伤性脑损伤（mTBI）后。本综述的目的是提供不同方法的概述，并提供SPECT、PET和MRS技术的最新发现的最新总结，特别是在标准化标准定义的mTBI后。鉴于不同的生理和病理反应是异质的，将努力在受伤后的不同时间点（急性、亚急性和慢性阶段）以及不同类型的mTBI（例如运动相关的头部损伤）进行单独研究，其中重复性头部损伤更为常见，并且可能呈现独特的特征。
Traumatic brain injury results in a metabolic cascade of changes that occur at the molecular level, invisible to conventional imaging methods such as computed tomography or magnetic resonance imaging. Non-invasive metabolic imaging tools such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance spectroscopy (MRS) are the ideal methods for providing insight to these changes by measuring regional cerebral blood flow, glucose metabolism, and brain metabolite concentrations, respectively, after mild traumatic brain injury (mTBI). The purpose of this review is to provide an overview of the different methodologies and provide an up-to-date summary of recent findings with SPECT, PET, and MRS technologies, specifically after mTBI, as defined by standardized criteria. Given that the different physiological and pathological responses are heterogeneous, efforts will be made to separate studies at different time points after injury (acute, subacute, and chronic stages) as well as to the different types of mTBI such sports-related head injury where repetitive head injuries are much more common and may present a unique signature.