Brain Activation Associated With Changes in Heart Rate, Heart Rate Variability, and Plasma Catecholamines During Rectal Distention
Brain Activation Associated With Changes in Heart Rate, Heart Rate Variability, and Plasma Catecholamines During Rectal Distention
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DOI：
10.1097/psy.0b013e31819b69ca
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发表时间：
2009-06
影响因子：
3.3
通讯作者：
Hideaki Suzuki;Satoshi Watanabe;T. Hamaguchi;H. Mine;T. Terui;Motoyori Kanazawa;Noriko Oohisa;M. Maruyama;T. Yambe;M. Itoh;S. Fukudo
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文献类型：
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作者：
Hideaki Suzuki;Satoshi Watanabe;T. Hamaguchi;H. Mine;T. Terui;Motoyori Kanazawa;Noriko Oohisa;M. Maruyama;T. Yambe;M. Itoh;S. Fukudo
目的：检验肠道刺激通过激活区域大脑皮层引发自主神经唤醒的假设。人脑如何处理内感受信号并形成初始自主唤醒是情感研究需要回答的关键问题之一。方法：十二名健康男性参与了这项研究。将恒压袋插入直肠并随机间歇地以 0、20 或 40 mm Hg 充气 80 秒。进行了脑部 H215O 正电子发射断层扫描 (PET)、心电图检查和儿茶酚胺血液采样。使用统计参数图解释局部脑血流量的变化。结果：40 mm Hg 的直肠扩张会导致心率、心率变异性的低频 (LF)/高频 (HF) 比率和血浆肾上腺素显着增加。直肠扩张期间与心率增加相关的激活大脑区域是右侧岛叶、右侧鳃盖、右侧背外侧前额叶皮层、壳核、丘脑、导水管周围灰质和小脑（p < .001，未校正），而与 LF/HF 比率增加相关的大脑区域是双侧岛叶、壳核、丘脑、中脑、脑桥和小脑。小脑（p < .001，未校正）。与血浆肾上腺素增加相关的激活大脑区域是右侧岛叶、右侧眶额皮质、右侧海马旁回、壳核、丘脑、导水管周围灰质、脑桥和小脑（p < .001，未校正）。结论：我们的结果表明，右侧岛叶和相关的身体映射区域可能形成响应肠道刺激的交感神经唤醒的功能模块。 PET = 正电子发射断层扫描； rCBF = 局部脑血流量； SPM = 统计参数映射； BA = 布罗德曼面积； ECG=心电图； HRV = 心率变异性； HF = HRV 的高频分量； LF = HRV 低频分量； LF/HF = LF 与 HF 之比； ANOVA = 方差分析； MRI = 磁共振成像。
Objective: To test the hypothesis that gut stimulation provokes autonomic arousal via activation of regional cerebral cortices. How the human brain processes interoceptive signals and forms initial autonomic arousal is one of the key questions to be answered in research on emotion. Methods: Twelve healthy males participated in this study. A barostat bag was inserted in the rectum and intermittently inflated with 0, 20, or 40 mm Hg at random for 80 seconds. H215O positron emission tomography (PET) of the brain, electrocardiography, and blood sampling for catecholamines were performed. Changes in regional cerebral blood flow were interpreted using statistical parametric mapping. Results: Rectal distention with 40 mm Hg induced a significant increase in heart rate, low frequency (LF)/high frequency (HF) ratio of heart rate variability, and plasma adrenaline. Activated brain areas that were associated with increased heart rate during rectal distention were the right insula, right operculum, right dorsolateral prefrontal cortex, putamen, thalamus, periaqueductal gray, and cerebellum (p < .001, uncorrected), whereas those that were associated with an increased LF/HF ratio were the bilateral insula, putamen, thalamus, midbrain, pons, and cerebellum (p < .001, uncorrected). Activated brain areas that were associated with increased plasma adrenaline were the right insula, right orbitofrontal cortex, right parahippocampal gyrus, putamen, thalamus, periaqueductal gray, pons, and cerebellum (p < .001, uncorrected). Conclusion: Our results suggest that the right insula and the related body mapping regions may form the functional module of sympathetic arousal in response to gut stimulation. PET = positron emission tomography; rCBF = regional cerebral blood flow; SPM = statistical parametric mapping; BA = Brodmann’s area; ECG = electrocardiogram; HRV = heart rate variability; HF = high frequency component of HRV; LF = low frequency component of HRV; LF/HF = ratio of LF to HF; ANOVA = analysis of variance; MRI = magnetic resonance imaging.