Long Non-Coding RNAs in Neuronal Aging.
Long Non-Coding RNAs in Neuronal Aging.
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DOI：
10.3390/ncrna4020012
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发表时间：
2018-04-18
期刊：
影响因子：
4.3
通讯作者：
Barry G
中科院分区：
文献类型：
--
作者：
Pereira Fernandes D;Bitar M;Jacobs FMJ;Barry G
生物体基因组中长链非编码RNA（lncRNA）的扩增与复杂调控网络的出现有关，这些网络可能有助于更复杂的神经过程，如高阶认知。与lncRNA在人脑正常功能中的重要作用一致，lncRNA表达的失调与衰老和年龄相关的神经退行性疾病有关。在本文中，我们讨论了已知的神经元相关的lncRNA的功能和表达，它们对表观遗传变化的影响，转座因子对lncRNA表达的贡献，以及lncRNA在维持神经元3D核结构中的意义。此外，我们还讨论了lncRNA在老年大脑中协调的复杂分子过程如何通过促进蛋白质聚集和神经变性来促进神经元发病机制。最后，这篇综述探讨了与年龄相关的lncRNA表达紊乱改变神经元的基因组和表观遗传调控景观的可能性，这可能会影响神经元的过程，如神经发生和突触可塑性。
The expansion of long non-coding RNAs (lncRNAs) in organismal genomes has been associated with the emergence of sophisticated regulatory networks that may have contributed to more complex neuronal processes, such as higher-order cognition. In line with the important roles of lncRNAs in the normal functioning of the human brain, dysregulation of lncRNA expression has been implicated in aging and age-related neurodegenerative disorders. In this paper, we discuss the function and expression of known neuronal-associated lncRNAs, their impact on epigenetic changes, the contribution of transposable elements to lncRNA expression, and the implication of lncRNAs in maintaining the 3D nuclear architecture in neurons. Moreover, we discuss how the complex molecular processes that are orchestrated by lncRNAs in the aged brain may contribute to neuronal pathogenesis by promoting protein aggregation and neurodegeneration. Finally, this review explores the possibility that age-related disturbances of lncRNA expression change the genomic and epigenetic regulatory landscape of neurons, which may affect neuronal processes such as neurogenesis and synaptic plasticity.