SYNTHESIS OF ETHENYLIDENEBIS(PHOSPHONIC ACID) AND ITS TETRAALKYL ESTERS
SYNTHESIS OF ETHENYLIDENEBIS(PHOSPHONIC ACID) AND ITS TETRAALKYL ESTERS
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DOI：
10.1021/jo00368a017
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发表时间：
1986-09-05
影响因子：
3.6
通讯作者：
BURDSALL, DC
中科院分区：
文献类型：
--
作者：
DEGENHARDT, CR;BURDSALL, DC
本文报道了一种合成亚乙烯基双膦酸四烷基酯的新方法。这两步程序涉及亚甲基双（膦酸酯）酯与多聚甲醛的碱催化反应，然后是甲醇的酸催化消除。描述了该方法第一步反应条件变化的影响。亚乙烯基双（膦酸）酯可以通过与溴三甲基硅烷反应转化为游离酸。
A new method for the preparation of tetraalkyl ethenylidenebis(phosphonates) has been developed. This two-step procedure involves the base-catalyzed reaction of a methylenebis(phosphonate) ester with paraformaldehyde followed by acid-catalyzed elimination of methanol. The effects of variation in the reaction conditions of the first step of this process are described. Ethenylidenebis(phosphonate) esters can be converted to the free acid by reaction with bromotrimethylsilane.