ANTIMICROBIAL SUSCEPTIBILITY OF STREPTOCOCCUS-MUTANS ISOLATED FROM PATIENTS WITH ENDOCARDITIS
ANTIMICROBIAL SUSCEPTIBILITY OF STREPTOCOCCUS-MUTANS ISOLATED FROM PATIENTS WITH ENDOCARDITIS
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DOI：
10.1128/aac.5.3.268
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发表时间：
1974-01-01
影响因子：
4.9
通讯作者：
THORNSBERRY, C
中科院分区：
文献类型：
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作者：
BAKER, CN;THORNSBERRY, C
41株变形链球菌（34株来自心内膜炎患者的血液标本，7株来自储备培养物）对青霉素、氨苄青霉素、甲氧西林、红霉素、头孢菌素、万古霉素、氯霉素、四环素、庆大霉素、链霉素和卡那霉素进行了敏感性试验。通过肉汤微量稀释法测定最小抑菌浓度和杀菌浓度。大多数菌株对氨苄西林、青霉素和红霉素非常敏感，大多数菌株的最低抑菌浓度为0.08 μg/ml或更低，大多数菌株对头孢噻吩、甲氧西林、氯霉素、四环素和万古霉素也敏感。庆大霉素是最有效的氨基糖苷类抗生素。抗生素敏感性模式与其他草绿色链球菌相似。一些微生物学家已经证明很难识别突变株。但是当生物体繁殖时。如果从心内膜炎患者中分离出变异链球菌，则至少应将其鉴定为非肠球菌性链球菌，以便开始适当的治疗。
Forty-one strains ofStreptococcus mutans(34 from blood specimens from patients with endocarditis and 7 from stock cultures) were tested for susceptibility to penicillin, ampicillin, methicillin, erythromycin, cephalothin, vancomycin, chloramphenicol, tetracycline, gentamicin, streptomycin, and kanamycin. Minimal inhibitory and bactericidal concentrations were determined by a broth microdilution procedure. Most of the strains were very susceptible to ampicillin, penicillin, and erythromycin, with most strains having minimal inhibitory concentrations of 0.08 μg/ml or less. Most of the strains were also susceptible to cephalothin, methicillin, chloramphenicol, tetracycline, and vancomycin. Gentamicin was the most effective aminoglycoside. The antimicrobial susceptibility patterns are similar to those of other viridans streptococci.S. mutansstrains have proven to be difficult for some microbiologists to identify. But when organisms suggestingS. mutansare isolated from patients with endocarditis, they should be at least identified as nonenterococcal streptococci so that appropriate therapy can be initiated.