AUTOANTIBODY TO CENTROMERE (KINETOCHORE) IN SCLERODERMA SERA
AUTOANTIBODY TO CENTROMERE (KINETOCHORE) IN SCLERODERMA SERA
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DOI：
10.1073/pnas.77.3.1627
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发表时间：
1980-01-01
期刊：
影响因子：
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通讯作者：
TAN, EM
中科院分区：
文献类型：
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作者：
MOROI, Y;PEEBLES, C;TAN, EM
硬皮病患者的血清含有几种针对核抗原的自身抗体，这些抗体可通过不同的核免疫荧光染色模式进行区分。一种自身抗体与染色体的着丝粒区域发生反应。在染色体扩散中，染色在着丝粒处表现为 2 个小球，类似于动粒。抗原决定簇似乎是与DNA紧密结合的蛋白质或多肽。该自身抗体与人类、小鼠和中国仓鼠细胞的着丝粒发生反应。自身抗体在硬皮病的钙质沉着症/雷诺现象/食管运动障碍/指端硬化/毛细血管扩张变异（CREST）中出现频率较高。
Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of nuclear immunofluorescence staining. One autoantibody reacted with centromeric regions of chromosomes. In chromosome spreads, the staining appeared as 2 small spheres at the centromere, resembling kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly bound to DNA. The autoantibody was reactive with centromeres of cells derived from humans, mice and Chinese hamsters. The autoantibody was present in high frequency in the calcinosis/Raynaud''s phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma.