The prevalence of thyroid nodules and its relationship with metabolic parameters in a Chinese community-based population aged over 40 years
The prevalence of thyroid nodules and its relationship with metabolic parameters in a Chinese community-based population aged over 40 years
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中国社区40岁以上人群甲状腺结节患病率及其与代谢参数的关系
DOI：
10.1007/s12020-013-9968-0
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发表时间：
2014-03-01
期刊：
影响因子：
3.7
通讯作者：
Duan, Yu
中科院分区：
文献类型：
--
作者：
Guo, Hongwei;Sun, Min;Duan, Yu
目的调查40岁以上社区人群甲状腺结节（TN）的患病率，并探讨TN与其代谢危险因素的关系。分析纳入了2011年6月至12月参加中国社区人群甲状腺结节流行病学调查的9，533名40岁以上成年人的数据。我们比较了TN组和健康对照组之间的代谢指标水平。TN患病率为46.6%（男性39.7%;女性50.3%），随年龄增长而显著增加（P < 0.001）.高血压组明显高于血压正常组（P < 0.001），血糖正常组为43.0%，糖尿病前期组为49.4%，糖尿病组为50.9%（P < 0.001）。Logistic回归分析显示，调整性别、年龄、体重指数、血脂水平、吸烟和饮酒等因素后，高血压[OR = 1.121（1.025-1.225）]、糖尿病前期和糖尿病[OR = 1.130（1.036-1.233）]均为TN的独立危险因素。老年人群TN患病率高。高血压、糖尿病前期和糖尿病可能是TN的独立危险因素。
To investigate the prevalence of thyroid nodules (TN) among a community population aged > 40 years and to explore the association between TN and its metabolic risk factors. Data from 9,533 adults aged over 40 years who participated in the epidemiological investigation of thyroid nodules in a Chinese community-based population from June to December 2011 were included in the analyses. We compared the levels of metabolic indices between the TN group and healthy controls. The prevalence of TN was 46.6 % (39.7 %, men; 50.3 %, women) and it increased significantly with increasing age (P < 0.001). It was significantly higher in the group with hypertension than in that with normotension (P < 0.001) and was 43.0 % in the normal blood glucose group, 49.4 % in the prediabetes group, and 50.9 % in the diabetes group (P < 0.001). Logistic regression analysis indicated that hypertension [odds ratio (OR) = 1.121 (1.025-1.225)] as well as prediabetes and diabetes [OR = 1.130 (1.036-1.233)] were all independent risk factors for TN after adjustment for sex, age, body mass index, blood lipid levels, smoking status, and alcohol consumption. The elderly population had a high prevalence of TN. Hypertension as well as prediabetes and diabetes might be independent risk factors for TN.