Longitudinal study of alcohol consumption and HDL concentrations: a community-based study
Longitudinal study of alcohol consumption and HDL concentrations: a community-based study
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DOI：
10.3945/ajcn.116.144832
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发表时间：
2017-04-01
影响因子：
7.1
通讯作者：
Gao, Xiang
中科院分区：
文献类型：
--
作者：
Huang, Shue;Li, Junjuan;Gao, Xiang
背景：横断面研究和短期临床试验表明，饮酒与HDL浓度之间存在正剂量-反应关系。然而，前瞻性数据有限。目的：在社区队列中，我们试图确定总酒精摄入量、含酒精饮料类型与6年（2006-2012）hdl -胆固醇浓度纵向变化之间的关系。设计：共纳入71379名中国成年人（平均年龄50岁），随访期间无心血管疾病和癌症且未使用降胆固醇药物。2006年通过一份调查问卷（基线）评估了酒精摄入量，并将参与者分为以下几类：从不饮酒、过去饮酒、轻度饮酒（女性：0-0.4份/天；男性：0-0.9份/天）、中度饮酒（女性：0.5-1.0份/天；男性：1-2份/天）和重度饮酒（女性：0- 1.0份/天；男性：1-2份/天）。在2006年、2008年、2010年和2012年测量了高密度脂蛋白胆固醇浓度。我们使用广义估计方程模型，在年龄、性别、吸烟、体育活动、肥胖、高血压、糖尿病、肝功能和c反应蛋白浓度调整后，检验基线酒精摄入量与高密度脂蛋白胆固醇浓度变化之间的关系。结果：观察到总饮酒量与hdl -胆固醇浓度变化之间呈伞状关联。与从不饮酒者相比，过去、轻度、中度和重度饮酒者的高密度脂蛋白胆固醇下降速度较慢，为0.012 mmol。l - 1。y(-1) (95% CI: 0.008, 0.016 mmol。l - 1。Y (-1)), 0.013 mmol。l - 1。y(-1) (95% CI: 0.010, 0.016 mmol。l - 1。Y (-1)), 0.017 mmol。l - 1。y(-1) (95% CI: 0.009, 0.025 mmol。l - 1。Y(-1))和0.008 mmol。l - 1。y(-1) (95% CI: 0.005, 0.011 mmol。l - 1。y(-1))分别(P
Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However, prospective data have been limited.Objective: We sought to determine the association between total alcohol intake, the type of alcohol-containing beverage, and the 6-y (2006-2012) longitudinal change in HDL-cholesterol concentrations in a community-based cohort.Design: A total of 71,379 Chinese adults (mean age: 50 y) who were free of cardiovascular diseases and cancer and did not use cholesterol-lowering agents during follow-up were included in the study. Alcohol intake was assessed via a questionnaire in 2006 (baseline), and participants were classified into the following categories of alcohol consumption: never, past, light (women: 0-0.4 servings/d; men: 0-0.9 servings/d), moderate (women: 0.5-1.0 servings/d; men: 1-2 servings/d), and heavy (women: >1.0 servings/d; men: >2 servings/d). HDL-cholesterol concentrations were measured in 2006, 2008, 2010, and 2012. We used generalized estimating equation models to examine the associations between baseline alcohol intake and the change in HDL-cholesterol concentrations with adjustment for age, sex, smoking, physical activity, obesity, hypertension, diabetes, liver function, and C-reactive protein concentrations.Results: An umbrella-shaped association was observed between total alcohol consumption and changes in HDL-cholesterol concentrations. Compared with never drinkers, past, light, moderate, and heavy drinkers experienced slower decreases in HDL cholesterol of 0.012 mmol . L-1 . y(-1) (95% CI: 0.008, 0.016 mmol . L-1 . y(-1)), 0.013 mmol . L-1 . y(-1) (95% CI: 0.010, 0.016 mmol . L-1 . y(-1)), 0.017 mmol . L-1 . y(-1) (95% CI: 0.009, 0.025 mmol . L-1 . y(-1)), and 0.008 mmol . L-1 . y(-1) (95% CI: 0.005, 0.011 mmol . L-1 . y(-1)), respectively (P