FRAX score and recent fall history predict the incidence for sarcopenia in community-dwelling older adults: a prospective cohort study
FRAX score and recent fall history predict the incidence for sarcopenia in community-dwelling older adults: a prospective cohort study
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DOI：
10.1007/s00198-020-05447-4
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发表时间：
2020-05-24
影响因子：
4
通讯作者：
Hagino, H.
中科院分区：
文献类型：
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作者：
Matsumoto, H.;Tanimura, C.;Hagino, H.
我们假设，基线FRAX评分和先前的跌倒将预测接受体检的社区居住的老年人中石棺减少的发生率。FRAX评分(危险比[HR]=1.087，95%可信区间1.014~1.167)和既往跌倒史(HR=5.181，95%可信区间1.002~26.777)是发生骨质疏松症的独立危险因素。目的探讨社区老年人体检后骨质疏松症的患病率和发生率，以及FRAX评分和跌倒病史是否能预测骨质疏松症的发生率。方法参与者是从一组登记参加城镇赞助的年度体检的个人中招募的。纳入研究的标准是年龄超过60岁，独立生活，以及在没有帮助的情况下行走的能力。接受护理的个人被排除在研究之外。共对426名居民参与者进行了分析。评估人口统计学信息、前一年的跌倒病史和无骨密度的FRAX评分。对肉质疏松症的评估是根据肉质疏松症亚洲工作组的建议进行的。结果最终用于评估石棺减少发生率的样本包括258名参与者。平均随访时间2.92年。骨质疏松症发生率为1.06例/100高危人群年。COX多因素Logistic回归模型调整了年龄、性别、肌肉质量和协变量，结果显示FRAX评分(HR=1.087，95%CI 1.014~1.167)和近期跌倒史(HR=5.181，95%CI 1.002~26.777)是骨质疏松症发生的独立危险因素。结论X线平片和跌倒病史可作为临床预防骨质疏松和骨质疏松症的简便筛查工具。
We hypothesized that the baseline FRAX score and previous falls would predict the incidence of sarcopenia in community-dwelling older adults who received medical check-ups. The FRAX score (hazard ratio [HR] = 1.087, 95% CI 1.014-1.167) and previous falls (HR = 5.181, 95% CI 1.002-26.777) were determined to be independent risk factors for the incidence of sarcopenia. Purpose This prospective study was performed to elucidate the prevalence and incidence of sarcopenia in community-dwelling older adults who received medical check-ups, and to determine whether FRAX score and fall history predict the incidence of sarcopenia. Methods Participants were recruited from a group of individuals who had registered for an annual town-sponsored medical check-up. Study inclusion criteria were aged older than 60 years, living independently, and ability to walk without assistance. Individuals who received nursing care were excluded from the study. A total of 426 residential participants were analyzed. Demographic information, fall history of the previous year, and FRAX score without bone mineral density were assessed. The assessment for sarcopenia was based on the recommendations of the Asian Working Group for Sarcopenia. Results The final sample for the assessment of sarcopenia incidence comprised 258 participants. The mean follow-up time was 2.92 years. The rate of sarcopenia was 1.06 cases per 100 person-years at risk. The Cox multivariate logistic regression model in our analysis was adjusted for age, gender, muscle mass, and covariates and showed that the FRAX score (HR = 1.087, 95% CI 1.014-1.167) and recent history of falls (HR = 5.181, 95% CI 1.002-26.777) were independent risk factors for the incidence of sarcopenia. Conclusion FRAX and history of falling can be a simple screening tool to raise awareness of the prevention of osteoporosis and sarcopenia in clinical settings.