Gastrointestinal Disorders in Parkinson's Disease: Prevalence and Health Outcomes in a US Claims Database
Gastrointestinal Disorders in Parkinson's Disease: Prevalence and Health Outcomes in a US Claims Database
复制标题
DOI：
10.3233/jpd-2011-001
复制
发表时间：
2011-01-01
影响因子：
5.2
通讯作者：
Richy, Florent
中科院分区：
文献类型：
--
作者：
Makaroff, Lydia;Gunn, Angus;Richy, Florent
大多数帕金森病（PD）患者最终会出现胃肠道疾病（GID），如吞咽困难、便秘和胃食管反流。本研究的目的是检查美国人群中PD患者的GID发生率，并检查GID患者的后续PD相关结局。在美国行政健康索赔数据库中，GID发病率随时间增加，在PD诊断后4年达到65%。为了进一步研究这种关系，对一个亚组的患者进行了更详细的分析。按年龄、性别、合并症、治疗方案、美国地区和计划类型匹配持续治疗的PD患者（伴和不伴GID）。他们的新兴健康结果被随访了两年。结果包括神经精神，运动和泌尿生殖系统障碍，以及医疗保健利用和成本。GIDs患者的性心理功能障碍、焦虑、抑郁、共济失调、疼痛、运动障碍、尿失禁和福尔斯的发生率较高。在GID患者的观察期间，急诊室入院，疼痛，睡眠和抑郁药物的数量，PD相关的医疗费用和非PD相关的医疗费用也增加了。这项研究表明，GID可能与某些PD相关结局的有害影响有关。
The majority of patients with Parkinson's Disease (PD) will eventually develop gastrointestinal disorders (GIDs) such as dysphagia, constipation and gastroesophageal reflux. The objectives of this study were to examine the incidence of GIDs in PD patients in a US population, and to examine subsequent PD-related outcomes in patients with GIDs. In a US administrative health claims database, GID incidence increased over time to reach 65% at four years after PD diagnosis. To further investigate this relationship, a subset of patients was analysed in greater detail. Continuously treated PD patients with and without GIDs were matched by age, gender, comorbidities, treatment regime, US region and plan type. Their emerging health outcomes were followed up for two years. Outcomes included neuropsychiatric, motor and urogenital disturbances, as well as healthcare utilization and costs. Patients with GIDs had higher rates of psychosexual dysfunction, anxiety, depression, ataxia, pain, movement disorders, urinary incontinence and falls. Emergency room admissions, the number of drugs for pain, sleep and depression, PD-related healthcare costs and non PD-related healthcare costs also increased during the observation period in GID patients. This study indicated that GIDs may be associated with deleterious effects on some PD-related outcomes.