EFFECTS OF RETINOIC ACID ON THE EXPRESSION OF RETINOIC ACID RECEPTORS DURING ZEBRAFISH EMBRYOGENESIS
EFFECTS OF RETINOIC ACID ON THE EXPRESSION OF RETINOIC ACID RECEPTORS DURING ZEBRAFISH EMBRYOGENESIS
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DOI：
10.1016/0925-4773(94)90082-5
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发表时间：
1994-05-01
影响因子：
2.6
通讯作者：
KRUIJER, W
中科院分区：
文献类型：
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作者：
JOORE, J;VANDERLANS, GBLJ;KRUIJER, W
分离编码视黄酸受体α（zRAR α）和γ（zRAR γ）的斑马鱼同源物的cDNA，并研究它们在正常和视黄酸（RA）处理的胚胎中的表达。在中枢神经系统中的表达边界明显不同于在小鼠中观察到的表达边界，这只能部分地由形态发生差异来解释。用RA处理胚胎诱导了前部脑结构中的异位zRAR γ表达以及眼睛中的zRAR α和zRAR γ表达。此外，在咽弓间充质中zRAR γ表达模式发生显著差异。由于所有这些结构的发育都已被证明受到外源性RA的影响，因此我们的数据表明zRAR α和zRAR γ在斑马鱼RA表型的建立中发挥着作用。
The cDNAs encoding the zebrafish homologs of retinoic acid receptor alpha (zRAR alpha) and gamma (zRAR gamma) were isolated and their expression studied in normal and retinoic acid (RA) treated embryos. Expression boundaries in the central nervous system are clearly different from those observed in the mouse, which can only partly be explained by morphogenetic differences. Treatment of embryos with RA induces ectopic zRAR gamma expression in anterior brain structures and both zRAR alpha and zRAR gamma expression in the eyes. Furthermore, striking differences occur in the zRAR gamma expression pattern in pharyngeal arch mesenchyme. Since the development of all of these structures has been shown to be affected by exogenous RA, our data suggest a role for zRAR alpha and zRAR gamma in the establishment of the RA phenotype in zebrafish.