Acetic acid activates distinct taste pathways in Drosophila to elicit opposing, state-dependent feeding responses
Acetic acid activates distinct taste pathways in Drosophila to elicit opposing, state-dependent feeding responses
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DOI：
10.7554/elife.47677
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发表时间：
2019-06-17
期刊：
影响因子：
7.7
通讯作者：
Axel, Richard
中科院分区：
文献类型：
--
作者：
Devineni, Anita V.;Sun, Bei;Axel, Richard
味觉回路是由基因决定的，它会引发一种天生的食欲或厌恶反应，确保动物食用有营养的食物，避免摄入毒素。我们研究了果蝇对醋酸的反应，醋酸是一种促味剂，可以是一种代谢资源，但也可以对果蝇有毒。我们的数据显示，苍蝇适应这些相互冲突的属性乙酸凭借饥饿依赖开关在他们的行为反应，这种刺激。进食的果蝇对乙酸表现出味觉厌恶，而饥饿的果蝇表现出强烈的食欲反应。这些相反的反应是由两种不同类型的味觉神经元介导的，即糖敏感神经元和糖敏感神经元。饥饿通过增强食欲糖通路以及抑制厌恶苦味通路，将行为反应从厌恶转变为吸引。因此，单一的促味剂可以通过激活由内部状态调节的不同味觉通路来驱动相反的行为。
Taste circuits are genetically determined to elicit an innate appetitive or aversive response, ensuring that animals consume nutritious foods and avoid the ingestion of toxins. We have examined the response of Drosophila melanogaster to acetic acid, a tastant that can be a metabolic resource but can also be toxic to the fly. Our data reveal that flies accommodate these conflicting attributes of acetic acid by virtue of a hunger-dependent switch in their behavioral response to this stimulus. Fed flies show taste aversion to acetic acid, whereas starved flies show a robust appetitive response. These opposing responses are mediated by two different classes of taste neurons, the sugar- and bitter-sensing neurons. Hunger shifts the behavioral response from aversion to attraction by enhancing the appetitive sugar pathway as well as suppressing the aversive bitter pathway. Thus a single tastant can drive opposing behaviors by activating distinct taste pathways modulated by internal state.