Testosterone supplementation therapy in the treatment of patients with metabolic syndrome.
Testosterone supplementation therapy in the treatment of patients with metabolic syndrome.
复制标题
DOI：
10.3810/pgm.2014.11.2843
复制
发表时间：
2014-11
影响因子：
4.2
通讯作者：
Lipshultz LI
中科院分区：
文献类型：
--
作者：
Kovac JR;Pastuszak AW;Lamb DJ;Lipshultz LI
代谢综合征（MetS）是一种临床复杂的危险因素，包括腰围增加、高甘油三酯、低HDL胆固醇、高血压和胰岛素抵抗，其存在增加了发展糖尿病和心血管疾病的可能性。由于四分之一的美国成年人口受到影响，MetS已被称为21世纪世纪最重大的公共卫生威胁。虽然建议改变生活方式和减肥，但没有具体的药物治疗。鉴于低水平的睾酮与代谢综合征的发病机制有关，并且循环睾酮与代谢综合征的发展之间存在反比关系，因此很容易推测代谢综合征患者可能受益于睾酮补充治疗（TST）。因此，本文旨在研究睾酮的作用以及TST作为男性MetS治疗方式的应用。
Metabolic syndrome (MetS) is a clinical complex of risk factors including increased waist circumference, high triglycerides, low HDL cholesterol, high blood pressure and insulin resistance whose presence increases the likelihood of developing diabetes and cardiovascular disease. With a quarter of the American adult population affected, MetS has been referred to as the most significant public health threat of the 21st century. While lifestyle modification and weight loss are recommended, no specific pharmacological treatment is known. Given that low levels of testosterone have been implicated in the pathogenesis of MetS and an inverse relationship exists between circulating testosterone and the development of MetS, it is tempting to speculate that men with MetS may benefit from testosterone supplementation therapy (TST). As such, this review seeks to examine the role of testosterone and the use of TST as a treatment modality in men with MetS.