Severe Obstructive Sleep Apnea Is Associated with Higher Brain Amyloid Burden: A Preliminary PET Imaging Study
Severe Obstructive Sleep Apnea Is Associated with Higher Brain Amyloid Burden: A Preliminary PET Imaging Study
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DOI：
10.3233/jad-200571
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发表时间：
2020-01-01
影响因子：
4
通讯作者：
Robinson, Stephen R.
中科院分区：
文献类型：
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作者：
Jackson, Melinda L.;Cavuoto, Marina;Robinson, Stephen R.
背景：阻塞性睡眠呼吸暂停（OSA）与痴呆风险增加有关。很少有研究对临床确诊的阻塞性睡眠呼吸暂停综合征是否与较高的脑淀粉样蛋白负荷相关进行横断面研究。目的：本研究的目的是比较未经治疗的阻塞性睡眠呼吸暂停综合征患者和健康对照者的脑淀粉样蛋白负荷，并探讨淀粉样蛋白负荷与多导睡眠图和睡眠、人口统计学和情绪的主观测量之间的关系。34名OSA患者（平均年龄57.5 ± 4.1岁; 19例男性）和12例对照（平均年龄58.5 ± 4.2岁; 6名男性）进行临床多导睡眠图和C-11-PiB正电子发射断层扫描（PET）以量化淀粉样蛋白负荷。相对于对照组，OSA组的淀粉样蛋白负荷升高，并且相对于轻度/中度OSA，重度OSA组的淀粉样蛋白负荷显著更高。相关性分析表明，较高的淀粉样蛋白负荷与较高的非REM呼吸暂停低通气指数，睡眠效率较差，并在N3睡眠阶段花费的时间较少，当控制age.Conclusion：严重的OSA与脑淀粉样蛋白的适度升高，其意义应进一步研究，探讨痴呆风险的影响。
Background: Obstructive sleep apnea (OSA) has been linked to an increase risk of dementia. Few studies have cross-sectionally examined whether clinically-confirmed OSA is associated with a higher brain amyloid burden.Objective: The aim of this study was to compare brain amyloid burden in individuals with untreated OSA and healthy controls, and explore associations between amyloid burden and polysomnographic and subjective measures of sleep, demographics, and mood.Methods: Thirty-four individuals with OSA (mean age 57.5 +/- 4.1 y; 19 males) and 12 controls (mean age 58.5 +/- 4.2 y; 6 males) underwent a clinical polysomnogram and a C-11-PiB positron emission tomography (PET) scan to quantify amyloid burden.Results: Amyloid burden was elevated in the OSA group relative to controls, and was significantly higher in those with severe OSA relative to mild/moderate OSA. Correlation analyses indicated that higher amyloid burden was associated with a higher Non-REM apnea hypopnea index, poorer sleep efficiency, and less time spent in stage N3 sleep, when controlling for age.Conclusion: Severe OSA is associated with a modest elevation of brain amyloid, the significance of which should be further investigated to explore the implications for dementia risk.