WHEN ASSESSING TWIN CONCORDANCE, USE THE PROBANDWISE NOT THE PAIRWISE RATE
WHEN ASSESSING TWIN CONCORDANCE, USE THE PROBANDWISE NOT THE PAIRWISE RATE
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DOI：
10.1093/schbul/18.2.171
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发表时间：
1992-01-01
影响因子：
6.6
通讯作者：
MCGUE, M
中科院分区：
文献类型：
--
作者：
MCGUE, M
长期以来，遗传学家和双胞胎研究人员一直在争论双胞胎一致性的两种替代测量方法的相对优点：成对一致性率和概率一致性率。这场辩论的结果现在是相当令人满意的，几乎在每一个应用中，概率率比两两率更受欢迎。然而，在最近对精神分裂症双胞胎研究的回顾中，Torrey（1992）选择了两两分析，而不是先验率。Torrey使用的成对比率使他得出结论，精神分裂症的同卵双胞胎一致性比广泛接受的要弱，而且，这暗示着，精神分裂症的遗传贡献的程度被高估了。在这篇简短的评论中，我们回顾了成对和概率率的相对优势和劣势，并表明Torrey的结论是基于他对成对率的错误使用。精神分裂症的双胞胎研究继续支持存在强烈的遗传影响精神分裂症的发展。
Geneticists and twin researchers have long debated the relative merits of two alternative measures of twin concordance: the pairwise and probandwise concordance rates. The results of this debate are now quite dear, for almost every application the probandwise rate is preferred over the pairwise rate. In a recent review of schizophrenia twin studies, however, Torrey (1992) chose to analyze pairwise rather than probandwise rates. Torrey's use of pairwise rates led him to conclude that the monozygotic twin concordance for schizophrenia is weaker than what is widely accepted, and that, by implication, the magnitude of the genetic contribution to schizophrenia has been overestimated. In this brief commentary, we review the relative strengths and weaknesses of the pairwise and probandwise rates and show that Torrey's conclusion is based upon his incorrect use of pairwise rates. Twin studies of schizophrenia continue to support the existence of a strong genetic influence on the development of schizophrenia.