Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects.
Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects.
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黑磷：具有固有和选择性化疗作用的生物活性纳米材料
DOI：
10.1002/anie.201810878
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Xue-Feng Yu
中科院分区：
文献类型：
--
作者：
Wenhua Zhou;Ting Pan;Haodong Cui;Zhen Zhao;Paul K Chu;Xue-Feng Yu
黑磷纳米片（BP）被证明是高度生物活性的抗癌剂，因为它们固有的和选择性的化疗效果。不同类型的癌细胞由于更强的细胞内氧化应激和加速的能量代谢，观察到BPs的快速细胞内生物降解和磷酸根阴离子的急性升高，但正常细胞不受影响。BP的选择性生物降解在癌细胞中诱导G2/M期阻滞和随后的细胞凋亡和自噬介导的细胞死亡，但在正常细胞中不诱导。其选择性上级优于传统化疗药物阿霉素（DOX）。 体内评估证实了BP抑制肿瘤生长的效率。这项研究提供了对纳米结构生物活性抗癌剂的见解，并揭示了纳米医学研究的新方向。
Black phosphorus nanosheets (BPs) are demonstrated to be highly bioactive anti‐cancer agents because of their inherent and selective chemotherapeutic effects. Fast intracellular biodegradation of BPs and acute elevation of phosphate anions were observed from different types of cancer cells due to the stronger intracellular oxidative stress and accelerated energy metabolism, but normal cells are not affected. Selective biodegradation of BPs induced G2/M phase arrest and subsequent apoptosis‐ and autophagy‐mediated cell death in cancer cells but not normal cells. The selectivity was superior to that of the traditional chemotherapeutic agent, doxorubicin (DOX). In vivo assessment confirmed the efficiency of BPs in suppressing tumor growth. This study provides insights into nanostructured bioactive anti‐cancer agents and reveals a new direction for nanomedicine research.