Inositol 1,4,5-trisphosphate is not effective in releasing calcium from skeletal sarcoplasmic reticulum microsomes.
Inositol 1,4,5-trisphosphate is not effective in releasing calcium from skeletal sarcoplasmic reticulum microsomes.
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肌醇 1,4,5-三磷酸不能有效地从骨骼肌浆网微粒体中释放钙。
DOI：
10.1016/0006-291x(85)91048-4
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发表时间：
1985
影响因子：
3.1
通讯作者：
J. Ferguson
中科院分区：
文献类型：
--
作者：
N. Scherer;J. Ferguson
许多细胞系统的调节已被证明是由肌醇1，4，5-三磷酸介导的，其导致钙从细胞内位点释放。我们已经表明，释放的Ca 2+从肌浆网微粒体不刺激IP 3。佛波醇酯TPA对Ca ~（2+）释放和Ca ~（2+）ATP酶活性也没有影响。因此，聚磷脂酰肌醇的分解不太可能作为第二信使来介导骨骼肌中Ca 2+的释放。
Regulation of many cell systems has been shown to be mediated by inositol 1,4,5-trisphosphate which causes a release of calcium from intracellular sites. We have shown that release of Ca2+from sarcoplasmic reticulum microsomes was not stimulated by IP3. The phorbol ester, TPA, also had no effect on Ca2+release or Ca2+ATPase activity. Thus, it is unlikely that the breakdown of polyphosphatidylinositides serves as a second messenger to mediate release of Ca2+in skeletal muscle.