INCREASED PREVALENCE OF HYPERTENSION AND LONG-TERM ARSENIC EXPOSURE
INCREASED PREVALENCE OF HYPERTENSION AND LONG-TERM ARSENIC EXPOSURE
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DOI：
10.1161/01.hyp.25.1.53
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发表时间：
1995-01-01
期刊：
影响因子：
8.3
通讯作者：
TAI, TY
中科院分区：
文献类型：
--
作者：
CHEN, CJ;HSUEH, YM;TAI, TY
为了研究长期接触无机砷与高血压患病率之间的关系，我们研究了居住在砷中毒高度流行村庄的382名男性和516名女性。高血压的定义是：收缩压大于或等于160 mm Hg，舒张压大于或等于95 mm Hg，或有高血压病史，定期服用抗高血压药物。根据标准化访谈获得的自来水井水消耗史和测量的井水砷浓度，计算长期砷暴露剂量。长期砷中毒高度流行的村庄的居民，经年龄和性别调整后的高血压患病率是非流行地区居民的1.5倍。自来水饮用时间、饮用水中平均砷浓度和累积砷暴露均与高血压患病率显著相关。累积砷暴露越高，高血压患病率越高。在调整了年龄、性别、糖尿病、蛋白尿、体重指数和血清甘油三酯水平后，这种剂量-反应关系仍然显著。这些结果表明，长期接触砷可能会导致人类高血压。
To examine the association between long-term exposure to inorganic arsenic and the prevalence of hypertension, we studied a total of 382 men and 516 women residing in villages where arseniasis was hyperendemic. Hypertension was defined as a systolic blood pressure of 160 mm Hg or greater, a diastolic blood pressure of 95 mm Hg or greater, or a history of hypertension treated regularly with antihypertensive drugs. The long-term arsenic exposure was calculated from the history of artesian well water consumption obtained through standardized interviews based on a structured questionnaire and the measured arsenic concentration in well water. Residents in villages where long-term arseniasis was hyperendemic had a 1.5-fold increase in age- and sex-adjusted prevalence of hypertension compared with residents in nonendemic areas. Duration of artesian well water consumption, average arsenic concentration in drinking water, and cumulative arsenic exposure were all significantly associated with hypertension prevalence. The higher the cumulative arsenic exposure, the higher the prevalence of hypertension. This dose-response relation remained significant after adjustment for age, sex, diabetes mellitus, proteinuria, body mass index, and serum triglyceride level. The results suggest that long-term arsenic exposure may induce hypertension in humans.