NCI, NHLBI/PBMTC First International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Endocrine Challenges-Thyroid Dysfunction, Growth Impairment, Bone Health, & Reproductive Risks
NCI, NHLBI/PBMTC First International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Endocrine Challenges-Thyroid Dysfunction, Growth Impairment, Bone Health, & Reproductive Risks
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DOI：
10.1016/j.bbmt.2011.10.006
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发表时间：
2011-12-01
影响因子：
4.3
通讯作者：
Petryk, Anna
中科院分区：
文献类型：
--
作者：
Dvorak, Christopher C.;Gracia, Clarisa R.;Petryk, Anna
儿童时期的内分泌系统极易受到造血细胞移植（HCT）前大剂量化疗和/或照射的损害。受HCT影响最大的特定内分泌器官包括甲状腺、垂体和性腺。此外，支持骨骼系统发育和稳定的激素也会受到影响。甲状腺激素不足是HCT最常见的晚期后遗症之一，多见于幼儿。缺乏垂体的生产生长激素是一个独特的问题，关注儿科人口。HCT的生殖风险取决于患者在进行HCT时的性别和青春期状态。青春期或性腺功能衰竭经常发生，尤其是在女性中。男女不育的风险仍然很高，而保留生育能力的方法在除青春期后男性之外的所有男性中都是有限的。HCT后的骨骼健康可能受到低骨密度和无血管坏死的影响，但在儿童HCT人群中关于这两个问题的数据有限。在本文中，知识的当前状态，知识的差距，以及对未来研究的建议都详细介绍了这些系统。中国血液与骨髓移植研究进展[j] .中国血液与骨髓移植杂志（英文版）
The endocrine system is highly susceptible to damage by high-dose chemotherapy and/or irradiation before hematopoietic cell transplantation (HCT) during childhood. The specific endocrine organs most affected by HCT include the thyroid gland, the pituitary, and the gonads. In addition, hormones that support development and stability of the skeletal system are also affected. Insufficiency of thyroid hormone is I of the most common late sequelae of HCT, and occurs more often in young children. Deficiency in the pituitary's production of growth hormone is a problem of unique concern to the pediatric population. The reproductive risks of HCT depend on the patient's gender and pubertal status at the time of HCT. Pubertal or gonadal failure frequently occurs, especially in females. Infertility risks for both genders remain high, whereas methods of fertility preservation are limited in all but postpubertal males. Bone health post-HCT can be compromised by low bone mineral density as well as avascular necrosis, but the data on both problems in the pediatric HCT population are limited. In this paper, the current state of knowledge, gaps in that knowledge, and recommendations for future research are addressed in detail for each of these systems. Biol Blood Marrow Transplant 17: 1725-1738 (2011) (C) 2011 American Society for Blood and Marrow Transplantation