Response of human tongue protrudor and retractors to hypoxia and hypercapnia
Response of human tongue protrudor and retractors to hypoxia and hypercapnia
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DOI：
10.1164/ajrccm.160.6.9903001
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发表时间：
1999-12-01
影响因子：
24.7
通讯作者：
Samara, GJ
中科院分区：
文献类型：
--
作者：
Mateika, JH;Millrood, DL;Samara, GJ
众所周知，在阻塞性睡眠呼吸暂停患者中，颧舌肌(舌头突出)在保护或增强上呼吸道通畅性方面具有作用。然而，到目前为止，还没有完成的研究涉及茎舌肌和舌肌(舌牵引器)在维持人类上呼吸道通畅中的作用。作为迈向这一目标的第一步，本研究旨在检测屏气动作和稳态低氧性高碳酸血症时人类舌头突出肌和伸缩肌的反应。结果表明，在这两种情况下，前伸肌和伸缩肌都被共同激活。对稳态低氧性高碳酸血症时肌电活动开始时间的测量表明，在吸气前或吸气早期，出现了时相的前伸和后缩活动。我们的结论是，在低氧和高二氧化碳状态下，舌前伸肌和牵引肌是共同激活的，在呼吸暂停和高呼吸暂停期间，舌牵拉肌可能在保护上呼吸道通畅方面起着重要作用。
It is well established that the genioglossus muscle (tongue protrudor) has a role in protecting or enhancing upper airway patency in individuals with obstructive sleep apnea. However, no investigation completed to date has addressed the role of the styloglossus and hyoglossus muscles (tongue retractors) in maintaining upper airway patency in humans. As a first step toward this goal, the present investigation was designed to examine the response of human tongue protrudor and retractor muscles during a breathhold maneuver and in steady-state hypoxic hypercapnia. The results showed that the protrudor and retractor muscles were coactivated under both conditions. Measurements of onset time of electromyographic activity during steady-state hypoxic hypercapnia revealed that phasic protrudor and retractor activity was initiated immediately before or during the early part of inspiration. We conclude that the tongue protrudor and retractor muscles are coactivated in response to hypoxia and hypercapnia, and that the tongue retractors may have a significant role in protecting upper airway patency during both apnea and hyperpnea.