High-performance wireless powering for peripheral nerve neuromodulation systems.

High-performance wireless powering for peripheral nerve neuromodulation systems.
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DOI:
10.1371/journal.pone.0186698
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发表时间:
2017
期刊:
影响因子:
3.7
通讯作者:
Poon ASY
Poon ASY
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Tanabe Y;Ho JS;Liu J;Liao SY;Zhen Z;Hsu S;Shuto C;Zhu ZY;Ma A;Vassos C;Chen P;Tse HF;Poon ASY

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使用生物电子设备对周围神经进行神经调节是治疗多种疾病的一种有前途的方法。无线供电可以使这些设备长期运行,但实现小型化和深埋设备的高性能仍然是一个技术挑战。我们报告了软神经调节装置(长 15 毫米,直径 2.7 毫米)中无线供电系统的小型化集成,并在猪动物模型中对迷走神经进行体内无线刺激时展示了高性能(约 10%)。性能的提高是通过产生聚焦圆偏振场来实现的,该场提高了效率并提供了对偏振失准的免疫力。这些性能特征确立了无线供电在基于神经调节的新兴疗法中的临床潜力。
Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model. The increased performance is enabled by the generation of a focused and circularly polarized field that enhances efficiency and provides immunity to polarization misalignment. These performance characteristics establish the clinical potential of wireless powering for emerging therapies based on neuromodulation.
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