High-performance wireless powering for peripheral nerve neuromodulation systems.
High-performance wireless powering for peripheral nerve neuromodulation systems.
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DOI:
10.1371/journal.pone.0186698
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发表时间:
2017
期刊:
影响因子:
3.7
通讯作者:
Poon ASY
中科院分区:
文献类型:
--
作者:
Tanabe Y;Ho JS;Liu J;Liao SY;Zhen Z;Hsu S;Shuto C;Zhu ZY;Ma A;Vassos C;Chen P;Tse HF;Poon ASY
Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model. The increased performance is enabled by the generation of a focused and circularly polarized field that enhances efficiency and provides immunity to polarization misalignment. These performance characteristics establish the clinical potential of wireless powering for emerging therapies based on neuromodulation.
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