Targeting carbohydrate antigens in HIV vaccine development.
Targeting carbohydrate antigens in HIV vaccine development.
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HIV 疫苗开发中的靶向碳水化合物抗原。
DOI：
10.1016/j.vaccine.2005.01.045
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Kieber-Emmons,Thomas
中科院分区：
文献类型：
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作者：
Pashov,Anastas;Canziani,Gabriela;Macleod,Stewart;Plaxco,Jason;Monzavi-Karbassi,Behjatolah;Kieber-Emmons,Thomas
肽模拟表位提供了增强人类免疫缺陷病毒1（HIV-1）特异性碳水化合物反应性免疫应答的策略。它们的抗原性和免疫学特性将取决于基序聚类和多聚化的优化。我们观察到相同模拟基序的结构变体，线性与环状，可用于调节所引发的抗体的性质。模拟表位序列基序数据库的扩展可以通过分析结合HIV定向单克隆抗体2G 12和凝集素伴刀豆球蛋白A（Con A）的结构来增加，从而促进新的模拟表位设计。这样的分析表明，这些试剂结合到包膜（env）蛋白上的甘露糖基抗原的子集。
Peptide mimotopes provide a strategy to augment human immunodeficiency virus 1 (HIV-1) specific carbohydrate reactive immune responses. Their antigenic and immunological properties will depend on the optimization of motif clustering and multimerization. We observe that structural variants of the same mimetic motif, linear versus cyclic, can be used to tune the properties of the antibodies elicited. The expansion of the database of mimotope sequence motifs can be increased by analyzing structures that bind to HIV directed monoclonal antibody 2G12 and the lectin Concanavalin A (Con A), fostering new mimotope designs. Such analysis indicates that these reagents bind to subsets of mannosyl antigens on the envelope (env) protein.