TRANSPORT OF VERY LOW-DENSITY LIPOPROTEIN TRIGLYCERIDES IN VARYING DEGREES OF OBESITY AND HYPERTRIGLYCERIDEMIA
TRANSPORT OF VERY LOW-DENSITY LIPOPROTEIN TRIGLYCERIDES IN VARYING DEGREES OF OBESITY AND HYPERTRIGLYCERIDEMIA
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DOI：
10.1172/jci109422
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发表时间：
1979-01-01
影响因子：
15.9
通讯作者：
BERMAN, M
中科院分区：
文献类型：
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作者：
GRUNDY, SM;MOK, HYI;BERMAN, M
用放射性甘油测定59例患者极低密度脂蛋白(VLDL)中甘油三酯(TG)的转运，测定其48h内的VLDL-TG比活性，并用多室分析进行数据处理。将患者分为3组：正常体重(89%~120%理想体重)、轻度肥胖(120%~135%理想体重)和重度肥胖(135%理想体重)。发现不同水平的极低密度脂蛋白-甘油三酯，从正常到显著升高。在许多受试者中，极低密度脂蛋白的浓度与转运呈正相关，表明极低密度脂蛋白-甘油三酯的过度产生导致了高甘油三酯血症。在其他受试者中，特别是在几个明显肥胖的受试者中，转运率大大增加，而没有明显的高甘油三酯血症，这表明他们清除甘油三酯的能力增强了。在所有组中，都有患者的高甘油三酯血症程度似乎与他们的转移率不成比例。这一发现以及许多患者在没有升高血浆甘油三酯的情况下VLDL-TG分泌增加的事实表明，VLDL-TG的过度产生和清除能力的不足都是导致高甘油三酯血症的原因之一。数据显示，由多室分析确定的转运速率与以前其他研究人员使用的单指数分析之间的相关性很差(r[相关系数]=0.46)；根据肥胖程度对患者进行隔离并没有改善这种比较。虽然需要两条转换路径(快速和慢速合成路径)来拟合数据，但传输速率与这两条路径的比率之间没有相关性。尽管已知极低密度脂蛋白转化为低密度脂蛋白的途径，但未发现极低密度脂蛋白-甘油三酯的转运速率与估计的低密度脂蛋白-胆固醇浓度之间的相关性。
Measurements of transport of triglycerides (TG) in very low lipoproteins (VLDL) were carried out in 59 patients by injection of radioactive glycerol, determinations of specific activities of VLDL-TG for 48 h thereafter and treatment of the data by multicompartmental analysis. The patients were divided into 3 groups: normal weight (89%-120% ideal weight), mildly obese (120%-135% ideal weight), and markedly obese (135% ideal weight). Varying levels of VLDL-TG were found, ranging from normal to markedly elevated. In many subjects, there was a positive correlation between concentrations and transport of VLDL indicating that overproduction of VLDL-TG contributed to hypertriglyceridemia. In others, and particularly in several markedly obese subjects, transport rates were greatly increased without significant hypertriglyceridemia, suggesting that they had enhanced capacity to clear TG. In all groups, there were patients whose degree of hypertriglyceridemia seemed out of proportion to their transport rates. This finding and the fact that many patients have increased secretion of VLDL-TG without elevated plasma TG suggests that both overproduction of VLDL-TG and insufficient enhancement of clearance contributed to the development of hypertriglyceridemia. The data showed a poor correlation between transport rates determined by the multicompartment analysis and single-exponential analysis used previously by other investigators (r [correlation coefficient] = 0.46); this comparison was not improved by segregating patients according to their degree of obesity. Although 2 conversion pathways (fast and slow synthetic paths) were required to fit the data, there was no correlation between transport rates and the ratio of the 2 pathways. Despite the known pathway of conversion of VLDL to low density lipoprotein, no correlation was found between VLDL-TG transport rates and estimated low density lipoprotein-cholesterol concentrations.