Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids
Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids
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DOI：
10.1039/d1ob00263e
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发表时间：
2021-04-08
影响因子：
3.2
通讯作者：
Busschaert, Nathalie
中科院分区：
文献类型：
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作者：
Herschede, Sarah R.;Gneid, Hassan;Busschaert, Nathalie
每年有越来越多的人感染抗药性细菌，有时会造成致命的后果。在这篇手稿中，我们报告了一种新的脲官能化冠醚，可以结合到细菌脂质磷脂酰乙醇胺（PE），促进PE触发器，并显示对革兰氏阳性细菌蜡样芽孢杆菌的抗菌活性，最低抑制浓度与已知的PE靶向lantibiotic duramycin相当。
An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin.