Population-based case-control study of cognitive function in essential tremor
Population-based case-control study of cognitive function in essential tremor
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DOI：
10.1212/01.wnl.0000192393.05850.ec
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发表时间：
2006-01-10
期刊：
影响因子：
9.9
通讯作者：
Bermejo-Pareja, F
中科院分区：
文献类型：
--
作者：
Benito-León, J;Louis, ED;Bermejo-Pareja, F
目的：确定与对照组相比，特发性震颤（ET）患者是否存在认知缺陷，以及是否在ET患者的大样本中也发现了先前报告的认知缺陷类型。研究方法：居住在西班牙中部的总共232名ET患者和696名年龄在65岁或以上（中位数75岁）的匹配对照（西班牙中部神经疾病研究）接受了神经心理学评估，包括整体认知表现、额叶执行功能、言语流畅性测试和记忆。受试者还被问及他们是否有健忘症。结果：五十六例ET患者先前未被诊断，只有14例（6%）正在服用震颤药物。根据年龄、性别、教育、病前智力、药物和抑郁症状进行调整后，病例在大多数神经心理学测试中表现较差，尤其是在整体认知能力测试中（37项简易精神状态检查=病例组27.0 +/- 6.7 vs对照组28.9 +/- 5.9，p < 0.001）和额叶执行功能（连线测试错误数= 8.7 +/- 11.0，病例组vs 3.8 +/- 7.6，p < 0.001）。117例（50.4%）ET患者与300例（43.1%）对照患者报告了遗忘（p = 0.05）。结论：在一个基于人群的样本中，大部分未经治疗的原发性震颤患者在正式的神经心理学测试中表现得比没有震颤的患者更差。在特发性震颤患者中，健忘的主诉也稍多见。
Objectives: To determine whether patients with essential tremor (ET) have cognitive deficits when compared with controls and whether the types of cognitive deficits reported previously are also found in this large sampling of patients with ET. Methods: A total of 232 patients with ET and 696 matched controls age 65 years or older (median 75 years) living in central Spain (the Neurologic Diseases in Central Spain study) underwent a neuropsychological assessment, including tests of global cognitive performance, frontal executive function, verbal fluency, and memory. Subjects also were asked whether they had forgetfulness. Results: Fifty-six patients with ET were previously undiagnosed; only 14 (6%) were taking medication for tremor. Adjusted for age, gender, education, premorbid intelligence, medications, and depressive symptoms, cases performed less well on most neuropsychological tests and especially tests of global cognitive performance (37-item Mini-Mental State Examination = 27.0 +/- 6.7 in cases vs 28.9 +/- 5.9 in controls, p < 0.001) and frontal executive function (Trail Making Test number of errors = 8.7 +/- 11.0 in cases vs 3.8 +/- 7.6 in controls, p < 0.001). Forgetfulness was reported in 117 (50.4%) patients with ET vs 300 (43.1%) controls (p = 0.05). Conclusions: In a population-based sample of largely untreated patients with essential tremor, cases performed more poorly on formal neuropsychological testing than did their counterparts without tremor. A complaint of forgetfulness was also marginally more common in patients with essential tremor.