Alcohol tolerance in a cholinergic nerve terminal: relation to the membrane expansion-fluidization theory of ethanol action.
Alcohol tolerance in a cholinergic nerve terminal: relation to the membrane expansion-fluidization theory of ethanol action.
复制标题
胆碱能神经末梢的酒精耐受性：与乙醇作用的膜膨胀流化理论的关系。
作者：
M. Curran;P. Seeman
通过乙醇对微型终板电位频率的影响来测量，接受长期乙醇处理的大鼠的膈神经末梢比蔗糖喂养的大鼠的膈神经末梢对乙醇（体外）具有更强的抵抗力。因此，长期接触乙醇可能会诱导更坚硬的膜脂质的合成，从而降低膜的“流化性”。这可能为乙醇耐受性以及与麻醉剂和巴比妥类药物的交叉耐受性提供神经细胞基础。
Phrenic nerve terminals from rats subjected to long-term ethanol treatment were more resistant to ethanol (in vitro) than terminals from sucrose-fed rats, as measured by the effect of ethanol on the frequency of miniature end plate potentials. Long-term ethanol exposure may thus induce the synthesis of more rigid membrane lipids, reducing membrane "fluidizability". This may provide a neurocellular basis for ethanol tolerance and cross-tolerance with anesthetics and barbiturates.