In vitro evaluation of minimum inhibitory concentration of several antibacterial agents against Rickettsia japonica using a plaque reduction assay system
In vitro evaluation of minimum inhibitory concentration of several antibacterial agents against Rickettsia japonica using a plaque reduction assay system
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DOI：
10.1016/j.jiac.2019.05.019
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发表时间：
2019-11-01
影响因子：
2.2
通讯作者：
Saijo, Masayuki
中科院分区：
文献类型：
--
作者：
Satoh, Masaaki;Kato, Hirofumi;Saijo, Masayuki
本研究旨在确定几种抗菌剂对引起日本斑疹热的日本立克次体的最低抑菌浓度（MIC）。采用体外培养法空斑减少试验测定了4种四环素类抗生素（四环素、多西环素、米诺环素和替加环素）、3种喹诺酮类抗生素（环丙沙星、氧氟沙星和左氧氟沙星）和2种大环内酯类抗生素（阿奇霉素和克拉霉素）对罗红霉素的MIC。日本的。R.日本产斑疹热立克次体对所测试的抗菌剂敏感，其MIC类似于在先前描述的空斑减少测定中确定的针对其它斑点热立克次体的MIC。(C)2019年日本化疗学会和日本传染病协会。由爱思唯尔有限公司出版。保留所有权利。
The study was conducted to determine the minimum inhibitory concentrations (MICs) of several antibacterial agents against Rickettsia japonica, which causes Japanese spotted fever. A plaque reduction assay as an in vitro culture method was conducted to determine the MICs of antibacterial agents (4 types of tetracyclines: tetracycline, doxycycline, minocycline, and tigecycline; 3 types of quinolones: ciprofloxacin, ofloxacin, and levofloxacin; and 2 types of macrolides: azithromycin and clarythromycin) against R. japonica. R. japonica was sensitive to the antibacterial agents tested with MICs similar to those against other spotted fever rickettsia determined in previously described plaque reduction assays. (C) 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.