Evidence for the Involvement of Resistin in Inflammation and Cardiovascular Disease
Evidence for the Involvement of Resistin in Inflammation and Cardiovascular Disease
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DOI：
10.2174/157339905774574392
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Fruehbeck, Gema
中科院分区：
文献类型：
--
作者：
Gomez-Ambrosi, Javier;Fruehbeck, Gema
肥胖症的患病率在全球范围内持续增加，其方式与2型糖尿病（T2DM）类似。过度肥胖和伴随的胰岛素抵抗通常与心血管疾病的发展有关。主要由脂肪细胞产生的循环激素抵抗素似乎在肥胖和炎症中增加，似乎在这种关联中发挥了作用。一些研究表明，T2DM患者的循环抵抗素浓度升高，尽管这些结果需要进一步证实。在严重炎症性疾病的患者中有抵抗素浓度升高的报道。然而，抵抗素在炎症发病和持续中的确切生理作用仍不清楚。抵抗素直接促进内皮细胞的活化，诱导内皮素-1的释放，增加粘附分子和趋化因子的表达，增强CD40配体的作用。本文综述了抵抗素生理学的最新进展，并分析了该激素在炎症和心血管疾病中的作用。
The prevalence of obesity continues to increase throughout the world in an analogous way to that of type 2 diabetes mellitus (T2DM). Excess adiposity and accompanying insulin resistance is frequently associated to the development of cardiovascular disease. The circulating hormone resistin, which is produced mainly by adipocytes and appears to be increased in obesity and inflammation, seems to play a role in this association. Some studies indicate that T2DM patients have increased circulating concentrations of resistin, although these results need further confirmation. Increased resistin concentrations have been described in patients with severe inflammatory disease. However, the precise physiological role of resistin in the pathogenesis and perpetuation of inflammation remains unclear. Resistin exerts direct effects to promote the activation of endothelial cells inducing the release of endothelin-1, increasing the expression of adhesion molecules and chemokines, and potentiating the effect of the CD40 ligand. The present review summarizes recent advances in understanding the physiology of resistin and analyzes the involvement of this hormone in inflammation and cardiovascular disease.