Reactions between benzo(a)pyrene and nucleobases by one-electron oxidation.
Reactions between benzo(a)pyrene and nucleobases by one-electron oxidation.
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苯并(a)芘和核碱基之间的单电子氧化反应。
DOI：
10.1093/jnci/49.6.1585
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
W. Girke
中科院分区：
文献类型：
--
作者：
M. Wilk;W. Girke
SummaryAdsorbed aromatic compounds were relatively easily oxidized. As active intermediates, radical cations occurred which, in carcinogenic compounds, preferred electrephilic substitutions to further oxidation. Benzo [a] pyrene in an adsorbed state could be oxidized by iodine in the presence of pyrimidines and purines. Some of the many products formed by adenine and purine were isolated and investigated spectroscopically. A 7-(or 9-) benzo [a] pyrenylpurine formed, and 6-aminobenzo [a] pyrene was a degradation product. The significance of oneelectron oxidation as a possible primary step in chemical carcinogenesis is discussed.
