The Direction of Longitudinal Associations Between Sleep Problems and Devession Symptoms: A Study of Twins Aged 8 and 10 Years
The Direction of Longitudinal Associations Between Sleep Problems and Devession Symptoms: A Study of Twins Aged 8 and 10 Years
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DOI：
10.1093/sleep/32.2.189
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发表时间：
2009-02-01
期刊：
影响因子：
5.6
通讯作者：
Eley, Thalia C.
中科院分区：
文献类型：
--
作者：
Gregory, Alice M.;Rijsdijk, Fruehling V.;Eley, Thalia C.
研究目的：建立儿童睡眠问题与抑郁症状之间纵向关联的方向和病因。设计：获得8岁和10岁双胞胎的数据。在评估中，父母完成了儿童睡眠习惯问卷，双胞胎完成了儿童抑郁问卷。背景：参与者主要在伦敦精神病学研究所接受采访。患者或参与者：300对双胞胎最初登记参加研究。干预：N/A。测量和结果：一个具有遗传信息的交叉滞后模型检验了睡眠和抑郁之间的联系。8岁时的睡眠问题预示着10岁时的抑郁(偏回归系数[95%可信区间]=0.10[0.01-0.18])。找不到相反的内容。睡眠问题随时间的稳定性主要是由基因造成的(10岁时对睡眠的遗传影响中，46%是由于对8岁时睡眠的相同基因影响)。抑郁的稳定性主要是由于非共享的环境影响(10岁时对抑郁的非共享环境影响中有19%是由于8岁时对抑郁的相同的非共享环境影响)。8岁的睡眠问题和10岁的抑郁症之间的交叉滞后关联主要是由于基因，尽管这一发现并不显著。结论：这项研究增加了我们对睡眠问题和抑郁症的时间优先顺序以及它们之间关联的风险的理解。明确与睡眠问题有关的基因的价值，以及在发展为更严重问题的关键时刻为高危人群提供早期干预策略的潜在机会，都具有一定的意义。
Study Objectives: To establish the direction and etiology of longitudinal associations between sleep problems and depression symptoms in children.Design: Data on twins aged 8 and 10 years were obtained. At assessments, parents completed the Child Sleep Habits Questionnaire, and twins completed the Children's Depression Inventory.Setting: Participants were mainly interviewed at the Institute of Psychiatry, London.Patients or Participants: Three hundred twin pairs initially enrolled in the study.Interventions: N/A.Measurements and Results: A genetically informative cross-lagged model examined links between sleep and depression. Sleep problems at age 8 predicted depression at age 10 (partial regression coefficient [95% confidence intervals] = 0.10 [0.01-0.18]). The converse was not found. Stability of sleep problems across time was mainly due to genes (46% of the genetic influence on sleep at 10 was due to the same genetic influence on sleep aged 8). Stability of depression was mainly due to nonshared environmental influences (19% of the nonshared environmental influence on depression at 10 was due to the same nonshared environmental influence on depression at age 8). The cross-lagged association between sleep problems at 8 and depression at 10 years was largely due to genes, although this finding was nonsignificant.Conclusions: This study adds to our understanding of the temporal precedence of sleep problems and depression and the risks underlying their associations. There are implications regarding the value of specifying genes linked to sleep problems and potential opportunities for informing early intervention strategies in high-risk groups at key points in the progression to developing more serious problems.