Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor.
Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor.
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DOI：
10.1155/2011/903918
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发表时间：
2011
影响因子：
2.8
通讯作者：
Sanders MM
中科院分区：
文献类型：
--
作者：
Anose BM;Sanders MM
锌指E-box结合蛋白1 （ZEB1）转录因子属于锌指同源结构域蛋白双成员家族，主要参与与细胞迁移和上皮向间质转化（EMTs）相关的生理和病理事件。ZEB1（也被称为δEF1， zfhx1a， TCF8和Zfhep）在调节t细胞发育，骨骼模式，繁殖和癌细胞转移等多种过程中发挥关键作用。然而，调控其表达的因子以及ZEB1参与的信号通路尚不明确。由于其受雌激素和孕激素诱导，在前列腺癌中含量高，我们研究了编码ZEB1的tcf8是否受雄激素调控。本研究的数据表明，tcf8在人PC-3/AR前列腺癌细胞系中是由双氢睾酮（DHT）诱导的，这种诱导是由两种雄激素反应元件（AREs）介导的。这些结果表明ZEB1是雄激素信号通路的中介。
The zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal transitions (EMTs). ZEB1 (also known as δEF1, zfhx1a, TCF8, and Zfhep) plays a key role in regulating such diverse processes as T-cell development, skeletal patterning, reproduction, and cancer cell metastasis. However, the factors that regulate its expression and consequently the signaling pathways in which ZEB1 participates are poorly defined. Because it is induced by estrogen and progesterone and is high in prostate cancer, we investigated whether tcf8, which encodes ZEB1, is regulated by androgen. Data herein demonstrate that tcf8 is induced by dihydrotestosterone (DHT) in the human PC-3/AR prostate cancer cell line and that this induction is mediated by two androgen response elements (AREs). These results demonstrate that ZEB1 is an intermediary in androgen signaling pathways.
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影响因子：
5.2
作者：
Kong, Dejuan;Li, Yiwei;Wang, Zhiwei;Banerjee, Sanjeev;Ahmad, Aamir;Kim, Hyeong-Reh Choi;Sarkar, Fazlul H.
通讯作者：
Sarkar, Fazlul H.
影响因子：
3.3
作者：
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影响因子：
4.8
作者：
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通讯作者：
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DOI：
10.1007/978-0-387-69080-3_55
发表时间：
2008-01-01
期刊：
HORMONAL CARCINOGENESIS V
影响因子：
--
作者：
Anose, Bynthia M.;LaGoo, Lisa;Schwendinger, Jamie
通讯作者：
Schwendinger, Jamie
影响因子：
20.3
作者：
Hidaka, Tomonori;Nakahata, Shingo;Morishita, Kazuhiro
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